Results 201 to 210 of about 37,595 (283)
Agonists and antagonists for excitatory amino acid receptors
Trends in Neurosciences, 1987 Abstract Behind the recent explosion of interest in the field, there lies a long period of relatively slow progress in the characterization of excitatory amino acid receptors. In this article, Jeff Watkins and Harry Olverman summarize the emergence of current ideas relating to receptor differentiation and describe some of the molecular features of ...
J.C. Watkins, Henry J. Olverman
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Dipsogenic effects of excitatory amino acid agonists in pigeons.
The Journal of Pharmacology and Experimental Therapeutics, 1993 Three excitatory amino acid agonists [N-methyl-D-aspartate (NMDA), kainate and alpha-amino-2,3-dihyro-5-methyl-3-oxo-4-isoxalzolepropanoic acid], each selective for separate glutamate binding sites, were evaluated for dipsogenic responses in pigeons. NMDA and kainate produced a reliable and rapid drinking response (up to 30% of body weight over 3 hr ...
Scott Baron, J H Woods
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Discriminative stimulus effects of excitatory amino acid agonists in rats
Neuropharmacology, 1995 Sixteen male Sprague-Dawley rats were trained to discriminate 30 mg/kg i.p. NMDA from saline using a 2-lever operant procedure. Responding was maintained under a FR 32 schedule of food reinforcement. Substitution tests were completed with NMDA (3-56 mg/kg) and other putative excitatory amino acids, L-glutamate (30-560 mg/kg), L-aspartate (30-300 mg/kg),
Doreen M. Grech +2 more
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The response of striatal neuropeptide Y and cholinergic neurons to excitatory amino acid agonists
Brain Research, 1988 The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT).
R.J. Boegman, André Parent
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European Journal of Pharmacology, 1993 The behavioral consequences of co-activation of metabotropic and ionotropic excitatory amino acid receptors were studied in mice using intracerebroventricular (i.c.v.) co-infusion of the metabotropic receptor agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylate (1S,3R-ACPD) with the subtype-specific ionotropic receptor agonists N-methyl-D-aspartate ...
Henrik Klitgaard, Peter Laudrup
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European Journal of Pharmacology, 1993 Intracerebroventricular (i.c.v.) infusion in mice of the selective metabotropic excitatory amino acid receptor agonist 1S,3R-1- aminocyclopentane-1,3-dicarboxylate (1S,3R-ACPD) (0.6-575 nmol/min) dose dependently induced face washing and scratching.
Peter Laudrup, Henrik Klitgaard
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Excitatory amino acids and rod photoreceptor disc shedding: Analysis using specific agonists
Experimental Eye Research, 1988 L-Glutamate and L-aspartate stimulate photoreceptor disc shedding. In order to evaluate the possible involvement of a receptor, we examined the effects of specific excitatory amino acid agonists on rod photoreceptor disc shedding and neural retinal toxicity.
Joseph C. Besharse, Gwendolyn Spratt
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Induction of locomotion in spinal tadpoles by excitatory amino acids and their agonists
Journal of Experimental Zoology, 1990 AbstractBath application of the excitatory amino acids L‐aspartate and/or L‐glutamate or their agonists N‐methyl‐D,L‐aspartate and/or kainate elicited swimming movements in spinal tadpoles. Swimming cycles induced by the amino acids were in the frequency range of natural movements, and could be evoked after sectioning all dorsal roots in the exposed ...
Philip Hugh Harrison
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Nature, 1986 Since the initial observations in the 1950s a large number of neurotransmitters and hormones have been shown to influence phosphatidylinositol (PI) metabolism in brain and peripheral ganglia (see ref. 3 for review). This has led to the suggestion that PI is part of an intracellular second messenger system for some types of diffusible chemical factors ...
Michel Baudry, Jim Evans, Gary Lynch
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