Results 211 to 220 of about 37,595 (283)

Metabolic, hormonal, and hemodynamic changes induced by metabotropic excitatory amino acid agonist (1S,3R)-ACPD

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1995
The purpose of the present study was to determine whether central administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), a selective metabotropic glutamate receptor agonist, would stimulate glucose metabolism, activate the hypothalamic-pituitary-adrenal axis, or influence pancreatic endocrine secretion.
Charles H. Lang, Mohammad Rehan Ajmal
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A 5-hydroxytryptamine2 agonist augments γ-aminobutyric acid and excitatory amino acid inputs to noradrenergic locus coeruleus neurons

Neuroscience, 1993
We examined the effects of the 5-hydroxytryptamine2 receptor agonist, (+-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, on spontaneous and evoked discharge of locus coeruleus neurons in the rat. Extracellular recordings were obtained from single locus coeruleus neurons while (+-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane was injected systemically ...
Chen‐Yu Chiang, Gary Aston‐Jones
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Domoic Acid Toxicity in Rats and Mice after Intracerebroventricular Administration: Comparison with Excitatory Amino Acid Agonists

Pharmacology & Toxicology, 1992
Abstract:A behavioural study of the domoic acid (DOM)‐induced convulsive behaviour after intracerebroventricular administration was carried out in rats and mice. DOM‐induced behaviours were compared to those elicited by other excitatory amino acid (EAA) agonists N‐methyl‐D‐aspartate (NMDA), α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA ...
Cristiano Chiamulera, Silvano Costa, Enzo Valerio, Angelo Reggiani   +3 more
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Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist

European Journal of Pharmacology, 1998
Adenosine has been reported to have beneficial effects against ischemic brain damage, although the mechanisms are not fully clarified. To examine the role of adenosine on the ischemia-evoked release of neurotransmitters, we applied a highly selective agonist for adenosine A1 receptor, 2-chloro-N6-cyclopentyladenosine (CCPA), into the ischemic brain ...
Haruyuki Goda, Hiroaki Ooboshi, Hiroshi Nakane, Setsuro Ibayashi, Seizo Sadoshima, Masatoshi Fujishima   +5 more
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Excitatory amino acid agonists. Enzymic resolution, x-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid

Journal of Medicinal Chemistry, 1989
The enantiomers of alpha-amino-4-bromo-3-hydroxy-5-isoxazolepropionic acid (4-bromohomoibotenic acid, Br-HIBO, 1) a selective and potent agonist at one class of the central (S)-glutamic acid receptors, were prepared with an enantiomeric excess higher than 98.8% via stereoselective enzymic hydrolysis of (RS)-alpha-(acetylamino)-4-bromo-3-methoxy-5 ...
Jan J. Hansen, Birgitte Nielsen, Povl Krogsgaard-Larsen, Lotte Brehm, Elsebet Ø. Nielsen, D.R. Curtis   +5 more
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A review of: “Excitatory Amino Acid Receptors, Design of Agonists and Antagonists”

Sulfur reports, 1993

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Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications

Pharmaceutica Acta Helvetiae, 2000
Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Specific receptors bind glutamate and some of these when activated open an integral ion channel and are thus known as ionotropic receptors. Within the ionotropic family of glutamate receptors, three major subtypes have been identified using classical ...
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Depolarization of retinal horizontal cells by excitatory amino acid neurotransmitter agonists

Neuroscience Letters, 1982
We have recorded the intracellular membrane potential of horizontal cells, second-order interneurones of the vertebrate retina, from fish retinae perfused with Ringer solution containing agonist drugs of the excitatory neurotransmitters, L-glutamate and L-aspartate.
J S, Rowe, K H, Ruddock
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Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.

Molecular Pharmacology, 1988
The properties of excitatory amino acid (EAA) receptors transplanted into Xenopus oocytes were investigated by voltage clamp 48 hr to 5 days after oocytes had been injected with mRNA isolated from rat brain. The application of EAA agonists to mRNA-injected cells, but not to uninjected or water-injected cells, produced several different inward currents,
T A, Verdoorn, R, Dingledine
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Neurotoxicity of excitatory amino acid receptor agonists in young rat hippocampal slices

Journal of Neuroscience Methods, 1989
Hippocampal slices from young (8-day-old) rats were evaluated as a model for investigating the mechanisms underlying the neurotoxic action of excitatory amino acid receptor agonists. The slices were exposed to the agonists for up to 30 min and were then postincubated for 90 min in order to allow irreversibly damaged cells to become visibly necrotic ...
G, Garthwaite, J, Garthwaite
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