Results 221 to 230 of about 37,595 (283)

Delayed Excitotoxic Neurodegeneration Induced by Excitatory Amino Acid Agonists in Isolated Retina

Journal of Neurochemistry, 1995
Abstract: Evidence from in vitro studies suggests that excitotoxic neuronal degeneration can occur by either an acute or delayed mechanism. Studies of the acute mechanism in isolated chick embryo retina using histological methods indicate that this process is rapidly triggered by activation of glutamate receptors of either the N‐methyl‐d‐aspartate ...
C, Romano, M T, Price, J W, Olney
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Intrathecal excitatory amino acid (EAA) agonists increase tail flick latencies (TFLs) of spinal rats

Pharmacology Biochemistry and Behavior, 1994
The facilitation of spinal nociceptive reflexes that occurs after spinal transection reveals the existence of descending, supraspinally mediated inhibition. Substantial evidence indicates that the excitatory amino acids (EAAs) are involved in these spinal circuits.
C, Advokat, A, Ghorpade, E, Wolf
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Excitotoxic lesions of histaminergic neurons by excitatory amino acid agonists in the rat brain

Neuroscience Letters, 1997
Excitotoxic lesions of histaminergic (HA) neurons in the rat hypothalamus were observed by the injection of ibotenate and N-methyl-D-aspartate (NMDA) while kainate, quisqualate and quinolinate had no significant effects on HA neurons. An NMDA selective antagonist, 2-amino-5-phosphonopentanoic acid, was able to block the toxic effects of both NMDA and ...
K, Yanai, X L, Zhao, T, Watanabe
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Induction of Primary Response Genes by Excitatory Amino Acid Receptor Agonists in Primary Astroglial Cultures

Journal of Neurochemistry, 1993
Abstract: We have characterized the genomic response of astroglial cells to excitatory amino acids by using selective agonists and antagonists for the various receptor subtypes and by analyzing different primary response genes, such as members of the Fos (c‐fos and fosB) and Jun (c‐jun, junB, and junD) families, zif/268, and c‐myc.
D. F. Condorelli, P. Dell'Albani, C. Amico, L. Kaczmarek, NICOLETTI, Ferdinando, K. Lukasiuk, A. M. Stella   +6 more
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Ethanol attenuates the response of locus coeruleus neurons to excitatory amino acid agonists in vivo

Naunyn-Schmiedeberg's Archives of Pharmacology, 1992
Recent in vitro electrophysiological studies have revealed that ethanol specifically reduces N-methyl-D-aspartate (NMDA)-activated ion currents, e.g. in hippocampal slices. In the present study, utilizing extracellular recording techniques, the effect of ethanol on excitatory amino acid induced excitability of rat locus coeruleus noradrenergic neurons ...
G, Engberg, M, Hajós
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Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: Dependence on calcium concentration

Neuroscience Letters, 1986
In slices of developing rat cerebellum, a 30-min application of the excitatory amino acid receptor agonist, N-methyl-D-aspartate (NMDA), led to the necrosis of differentiating granule cells and deep nuclear neurones. The corresponding effect of another agonist, kainate, was the death of Golgi cells.
G, Garthwaite, J, Garthwaite
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ChemInform Abstract: Design of Excitatory Amino Acid Receptor Agonists, Partial Agonists, and Antagonists: Ibotenic Acid as a Key Lead Structure

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. KROGSGAARD‐LARSEN, B. EBERT, T. M. LUND, H. BRAEUNER‐OSBORNE, F. A. SLOEK, T. N. JOHANSEN, L. BREHM, U. MADSEN   +7 more
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Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists.

Arzneimittel-Forschung, 1996
In traditional Chinese medicine, a mixture of radish and pepper is used to treat epilepsy. The presumptive effectiveness of this prescription might be due to the anticonvulsant actions of the principal component of pepper, the alkaloid piperine (CAS 94-62-2).
d' Hooge, Rudi, Pei, Y.-Q., Raes, Adam, Lebrun, P., van Bogaert, Pierre Paul, De Deyn, Peter Paul   +5 more
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Epinephrine and norepinephrine modulate neuronal responses to excitatory amino acids and agonists in frog spinal cord

Synapse, 1987
AbstractThe interaction of catecholamines epinephrine (E) and norepinephrine (NE) (1.0–100 μM) and excitatory amino acids on motoneurons of the isolated superfused frog spinal cord was investigated by sucrose gap recordings from ventral roots. Exposure of the cord to E or NE 30 sec prior to application of L‐aspartate or L‐glutamate reduced the ...
C J, Wohlberg, J C, Hackman, R A, Davidoff   +2 more
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Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina

Journal of Neurophysiology, 1993
1. Whole-cell patch-clamp recordings were obtained from ON bipolar cells in a retinal slice preparation of the mudpuppy, Necturus maculosus. The effects of excitatory amino acid (EAA) agonists applied in the presence of cobalt (2-5 mM) were examined. 2.
W B, Thoreson, R F, Miller
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