Results 91 to 100 of about 43,942 (341)

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source

Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, EarlyView.
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden, Raquel Alonso‐Román, Johannes Stallhofer, Mark S. Gresnigt, Bernhard Hube, Alexander S. Mosig   +5 more
wiley   +1 more source

Excitatory amino acid antagonists and Parkinson's disease [Reply to letter to the editor] [PDF]

, 1990
Girault et al. draw similar conclusions from their studies of the regulation of protein phosphorylation by dopamine and glutamate in striatonigral neurones as we did on the basis of behavioural findings, i.e. that dopamine and glutamate may exert opposite effects within the neostriatum.
Schmidt, Werner J., Bubser, Michael, Hauber, Wolfgang   +2 more
openaire   +2 more sources

In Situ‐Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)‐Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing

Advanced Healthcare Materials, EarlyView.
In situ‐gelling poly(oligoethylene glycol methacrylate) (POEGMA)‐based hydrogels exhibit broad‐spectrum antibacterial activity against both gram‐positive and gram‐negative bacteria based on the dual covalent attachment of quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP) into the hydrogel networks, enabling effective in vivo burn ...
Fei Xu, Evelyn Cudmore, Sadru‐Dean Walji, Lei Zhang, Meghan Kostashuk, Isabella Jun, Gurpreet Randhawa, Zhicheng Pan, Todd Hoare   +8 more
wiley   +1 more source

Bol i ekscitatorne aminokiseline [PDF]

Vojnosanitetski Pregled, 2002
Jelenković Ankica V., Veskov Rosica, Jovanović Marina D., Raičević Ranko, Bokonjić Dubravko, Vasilev-Pešić Vesna, Bošković Bogdan   +6 more
doaj   +1 more source

Indigenous amino acids in primitive CR meteorites [PDF]

arXiv, 2008
CR meteorites are among the most primitive meteorites. In this paper, we report the first measurements of amino acids in Antarctic CR meteorites, two of which show the highest amino acid concentrations ever found in a chondrite. EET92042, GRA95229 and GRO95577 were analyzed for their amino acid content using high performance liquid chromatography with ...
arxiv  

Neuroprotective Effect of Excitatory Amino Acid Receptor Antagonist on Retina of Rat [PDF]

, 2021
Chuanfeng Fan, Wenguo Feng, Jingchang Yang, Qingchao Chen, Yu Tian Wang   +4 more
openalex   +1 more source

Glycine-induced neurotoxicity in organotypic hippocampal slice cultures [PDF]

, 2018
The role of the neutral amino acid glycine in excitotoxic neuronal injury is unclear. Glycine coactivates glutamate N-methyl-D-aspartate (NMDA) receptors by binding to a distinct recognition site on the NR1 subunit.
Barth, A., Barth, L., Newell, D., Nguyen, L.   +3 more
core