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THE BEHAVIORAL-EFFECTS OF EXCITATORY AMINO-ACID (EAA) ANTAGONISTS

, 2016
Iversen, S, Singh, L, Oles, R, Tricklebank, M   +3 more
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Anticonvulsant Action of Excitatory Amino Acid Antagonists

Science, 1982
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N ...
Croucher, M J, Collins, J F, Meldrum, B S   +2 more
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Muscle relaxant action of excitatory amino acid antagonists

Neuroscience Letters, 1985
Antagonists of neuronal excitation induced by dicarboxylic amino acids were tested in genetically spastic rats of the Han-Wistar strain. These animals exhibit an increased muscle tone which can be measured as a spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Compounds that block excitation due to N-methyl-D-aspartic
L, Turski, M, Schwarz, W A, Turski, T, Klockgether, K H, Sontag, J F, Collins   +5 more
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Interactions of excitatory amino acid antagonists with conventional antiepileptic drugs

Metabolic Brain Disease, 1996
Excitatory amino acid antagonists possess anticonvulsant properties in many experimental models of epilepsy and were shown to potentiate the protective activity of conventional antiepileptics against maximal electroshock-induced seizures in mice. Combined treatments of valproate with either D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid or ...
S J, Czuczwar, W A, Turski, Z, Kleinrok
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6 Excitatory amino acid antagonists

Baillière's Clinical Anaesthesiology, 1996
Summary l -glutamate is a major excitatory neurotransmitter in the mammalian central nervous system. It acts through ion channel receptors of the AMPA and NMDA subtypes, and selective antagonists acting on these receptors are available. Both in vitro and in vivo animal studies have demonstrated that glutamate antagonists, particularly those acting ...
Leslie L. Iversen, Kennedy R. Lees
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Protective role of excitatory amino acid antagonists in experimental retinal ischemia

Graefe's Archive for Clinical and Experimental Ophthalmology, 1995
Excitatory amino acids and their analogues (NMDA, kainate and AMPA) are implicated in the pathogenesis of ischemic brain injury. In order to fully understand their involvement in the pathogenesis of retinal ischemic injury, we studied the electrophysiological and histopathological effects of two excitatory amino acid antagonists, cis-PDA and MK 801, in
M, Weber, N, Bonaventure, J A, Sahel
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Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists

Canadian Journal of Physiology and Pharmacology, 1985
The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-α-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or ...
C A, Colton, J S, Colton
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Excitatory amino acid antagonists and Parkinson's disease

Trends in Neurosciences, 1990
J A, Girault, S, Halpain, P, Greengard
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