Results 271 to 280 of about 44,108 (332)

Neuro-immune-tumor axis in gliomas: a review of mechanisms, models, and translational opportunities. [PDF]

Front Immunol
Xu L, Chen S, Fu Y, Zhou T, Yu J, Li J, Chen W.   +6 more
europepmc   +1 more source

Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms. [PDF]

Int J Mol Sci
Saldaña R, Carrascosa AJ, Torregrosa AB, Navarrete F, García-Gutiérrez MS, Manzanares J.   +5 more
europepmc   +1 more source

THE BEHAVIORAL-EFFECTS OF EXCITATORY AMINO-ACID (EAA) ANTAGONISTS

, 2016
Iversen, S, Singh, L, Oles, R, Tricklebank, M   +3 more
openaire   +1 more source

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Muscle relaxant action of excitatory amino acid antagonists

Neuroscience Letters, 1985
Antagonists of neuronal excitation induced by dicarboxylic amino acids were tested in genetically spastic rats of the Han-Wistar strain. These animals exhibit an increased muscle tone which can be measured as a spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Compounds that block excitation due to N-methyl-D-aspartic
L, Turski, M, Schwarz, W A, Turski, T, Klockgether, K H, Sontag, J F, Collins   +5 more
openaire   +4 more sources

Interactions of excitatory amino acid antagonists with conventional antiepileptic drugs

Metabolic Brain Disease, 1996
Excitatory amino acid antagonists possess anticonvulsant properties in many experimental models of epilepsy and were shown to potentiate the protective activity of conventional antiepileptics against maximal electroshock-induced seizures in mice. Combined treatments of valproate with either D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid or ...
S J, Czuczwar, W A, Turski, Z, Kleinrok
openaire   +4 more sources

The isomers of 2-amino-5-phosphonovalerate as excitatory amino acid antagonists—A reappraisal

European Journal of Pharmacology, 1982
Abstract The previously reported qualitative similarity of action of the optical isomers of 2-amino-phosphonovalerate (AVP) as antagonists of certain excitatory amino acid actions is incorrect. Optically pure L(+)-APV is devoid of such effect; its only action upon neurones may be a very slight excitatory one.
openaire   +4 more sources

Isomers of cyclazocine as excitatory amino acid antagonists

Neuropeptides, 1984
Abstract As an N-methylaspartate antagonist on cat and frog spinal neurones, (−) cyclazocine was twice as potent as (+) cyclazocine. This stereoselectivity is similar to that of cyclazocine at sigma rather than at mu or kappa opiate receptors. Cyclazocine also reduced synaptic excitation in rat cortex.
D, Lodge, S C, Berry, J, Church, D, Martin, A, McGhee, H M, Lai, A M, Thomson   +6 more
openaire   +2 more sources

Noncompetitive excitatory amino acid receptor antagonists

Trends in Pharmacological Sciences, 1990
In the first article in this series, Watkins, Krogsgaard-Larsen and Honoré outlined the structure-activity requirements at the receptor sites for excitatory amino acids in the mammalian CNS. The postsynaptic depolarizing actions of glutamate are thought to be mediated by NMDA, AMPA and kainate receptors. Here David Lodge and Kenneth M.
D, Lodge, K M, Johnson
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Anticonvulsant Action of Excitatory Amino Acid Antagonists

Science, 1982
Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N ...
Croucher, M J, Collins, J F, Meldrum, B S   +2 more
openaire   +2 more sources