Results 301 to 310 of about 43,942 (341)
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Anticonvulsant Action of Excitatory Amino Acid Antagonists
Science, 1982Compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy, namely sound-induced seizures in DBA/2 mice and threshold pentylenetetrazol seizures in Swiss mice. Sound-induced seizures could be prevented by intracerebroventricular injection of compounds that block excitation due to N ...
Croucher, M J +2 more
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Muscle relaxant action of excitatory amino acid antagonists
Neuroscience Letters, 1985Antagonists of neuronal excitation induced by dicarboxylic amino acids were tested in genetically spastic rats of the Han-Wistar strain. These animals exhibit an increased muscle tone which can be measured as a spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Compounds that block excitation due to N-methyl-D-aspartic
Lechoslaw Turski +5 more
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Clinical Experience With Excitatory Amino Acid Antagonist Drugs
Stroke, 1995Background Excitotoxic damage due to excess release of neuronal glutamate is hypothesized to play a pivotal role in the pathogenesis of focal cerebral ischemia. Drugs that antagonize excitatory amino acid function are consistently neuroprotective in preclinical models of stroke, and many are now entering clinical trials.
Kennedy R. Lees, Keith W. Muir
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Non-competitive antagonists of excitatory amino acid receptors
Trends in Neurosciences, 1987Abstract Non-competitive antagonists have become important tools for investigating the basic mechanisms of NMDA receptor function. Such compounds (e.g. MK-801, PCP) are thought to act at the level of the NMDA receptor-associated ion channel and many show a marked use-dependence in their antagonist properties.
E. Wong, Alan C. Foster, John A. Kemp
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Antagonists of excitatory amino acids and cyclic guanosine monophosphate in cerebellum
Neuropharmacology, 1982The excitatory amino acid analogues kainate, quisqualate, domoic acid, 4-fluoroglutamate, homocysteic acid and N-methylaspartate as well as the tremor-inducing drugs harmaline and oxotremorine all induced significant elevations in cyclic guanosine monophosphate (cGMP) levels in the cerebellum in vivo. The putative antagonists of excitatory amino acids,
N. P. V. Nair +3 more
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Neuroprotective Actions of Excitatory Amino Acid Receptor Antagonists
1994Publisher Summary Postischemic neuronal degeneration is caused in part by overactivity of excitatory amino acid (EAA) neurotransmitter systems. Increases in extracellular glutamate levels result in glutamate receptor-mediated increases in postsynaptic intracellular calcium levels.
V.L. Woodburn, G.N. Woodruff
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Interactions of excitatory amino acid antagonists with conventional antiepileptic drugs
Metabolic Brain Disease, 1996Excitatory amino acid antagonists possess anticonvulsant properties in many experimental models of epilepsy and were shown to potentiate the protective activity of conventional antiepileptics against maximal electroshock-induced seizures in mice. Combined treatments of valproate with either D,L-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid or ...
Zdzisław Kleinrok +2 more
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Action of excitatory amino acids and their antagonists on hippocampal neurons
Cellular and Molecular Neurobiology, 1985Intracellular recordings were obtained from guinea pig hippocampal neurons maintained in vitro. Current- and voltage-clamp techniques were used to study the effect of microiontophoresis of excitatory amino acid agonists. Modification of agonist responses by bath application of known concentrations of antagonist agents was also examined.
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Depression of decerebrate rigidity in the rat by antagonists of excitatory amino acids
Neuropharmacology, 1989Effects of intravenous antagonists of excitatory amino acids on decerebrate rigidity in the rat were examined. Kynurenate, ketamine, (4S, 5R)-4-(2-methylpropyl)-3-[3-(perhydroazepin-1-yl)propyl]-5-phenyl- 1,3- oxazolidin-2-one hydrochloride (MLV-6976), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclo-hepten-5,10-imine maleate (MK-801), 3-((/-)-2 ...
Y. Goto, M. Ishida, Haruhiko Shinozaki
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Structure-activity relations of dipeptide antagonists of excitatory amino acids
Neuroscience, 1984Structure-activity relations of dipeptides related to gamma-D-glutamylglycine have been investigated with respect to the ability of these substances to antagonize depolarizing responses of frog motoneurones in vitro to N-methyl-D-aspartate, kainate and quisqualate.
A.W. Jones +2 more
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