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Excitatory Amino Acid Antagonists as Novel Anticonvulsants
1986The convulsant effect of application of dicarboxylic amino acids to the cortex was first reported by Hayashi (1954). This observation suggests that antagonists of excitation induced by amino acid neurotransmitters might be anticonvulsant agents in some forms of epilepsy. Some rather weak and indeterminate anticonvulsant effects of glutamic acid diethyl
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Excitatory amino acid receptor subtypes and specific antagonists
Medicinal Research Reviews, 1989Article de synthese sur le site de reconnaissance des recepteurs, le ionophore, l'unite modulatrice, les determinations du poids moleculaire, les ...
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Methyltetrahydrofolate as an antagonist of excitatory amino acids on spinal neurones
European Journal of Pharmacology, 1982Folate and N5-methyl-5,6,7,8-tetrahydrofolate (MTHF) have been reported to have excitatory effects upon cortical neurones, possibly due to interaction with kainate receptors. On spinal neurones these compounds have been found inactive as excitants; however MTHF is a weak antagonist of kainate and N-methyl-D-aspartate excitations, and less effectively ...
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Phosphorus, Sulfur, and Silicon and the Related Elements, 1996
Abstract Decahydroisoquinoline-3-carboxylic acids, substituted at C-6 with an acidic moiety such as a phosphonic, sulfonic or carboxylic acid or tetrazole, were prepared as antagonists of excitatory amino acid (EAA) receptors.
Arnold Macklin Brian +3 more
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Abstract Decahydroisoquinoline-3-carboxylic acids, substituted at C-6 with an acidic moiety such as a phosphonic, sulfonic or carboxylic acid or tetrazole, were prepared as antagonists of excitatory amino acid (EAA) receptors.
Arnold Macklin Brian +3 more
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Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications
Pharmaceutica Acta Helvetiae, 2000Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Specific receptors bind glutamate and some of these when activated open an integral ion channel and are thus known as ionotropic receptors. Within the ionotropic family of glutamate receptors, three major subtypes have been identified using classical ...
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Neuroscience Letters, 1984
Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness.
Howard V. Wheal, Anne E. King
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Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness.
Howard V. Wheal, Anne E. King
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Protective role of excitatory amino acid antagonists in experimental retinal ischemia
Graefe's Archive for Clinical and Experimental Ophthalmology, 1995Excitatory amino acids and their analogues (NMDA, kainate and AMPA) are implicated in the pathogenesis of ischemic brain injury. In order to fully understand their involvement in the pathogenesis of retinal ischemic injury, we studied the electrophysiological and histopathological effects of two excitatory amino acid antagonists, cis-PDA and MK 801, in
Michel Weber +2 more
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Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists
Canadian Journal of Physiology and Pharmacology, 1985The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-α-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or ...
Carol A. Colton, Joel S. Colton
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Interaction of ethanol with excitatory amino acid receptor antagonists in mice
European Journal of Pharmacology, 1999The purpose of the present study was to determine whether the motor impairment (myorelaxation/ataxia) induced by excitatory amino acid receptor antagonists was exaggerated by pretreatment with ethanol. The results were compared with those of gamma-aminobutyric acid(A) (GABA(A)) receptor positive modulators alone and in combination with ethanol.
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Effects of excitatory amino acid antagonists on social recognition of male rats
Behavioural Pharmacology, 1994The effects of NMDA and non-NMDA glutamate receptor antagonists were evaluated on social recognition of adult male rats. Adult animals were injected (s.c.) with drug or saline immediately after the initial exposure to a juvenile male, 21-24 days old, and re-exposed to the same or to a novel juvenile 30min later.
Hlinák Z, Krejcí I
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