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Role of Excitatory Amino Acid Antagonists in the Management of Birth Asphyxia
Neonatology, 1992Birth asphyxia is an important cause of permanent neuro-developmental disability. Asphyxia sets in course a progression of intracellular events which culminates in neuronal death, and this process may take up to 48 h to complete. Entry of calcium into the neurone appears to be the key to the cell death, and it is known that during asphyxia, excessive ...
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European Journal of Medicinal Chemistry, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Madsen, U +7 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Madsen, U +7 more
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Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters
Clinical Science, 1985The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry.
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The isomers of 2-amino-5-phosphonovalerate as excitatory amino acid antagonists—A reappraisal
European Journal of Pharmacology, 1982Abstract The previously reported qualitative similarity of action of the optical isomers of 2-amino-phosphonovalerate (AVP) as antagonists of certain excitatory amino acid actions is incorrect. Optically pure L(+)-APV is devoid of such effect; its only action upon neurones may be a very slight excitatory one.
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Quinoxalinediones as Excitatory Amino Acid Antagonists in The Vertebrate Central Nervous System
1990Publisher Summary Excitatory amino-acid receptors (EAARs) are the prime mediators of fast excitatory synaptic transmission in the vertebrate central nervous system (CNS). These receptors are currently classified into five subtypes: N -methyl- d -aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate, L -2-amino-4 ...
Stephen N. Davies +1 more
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Hyperpolarization of retinal horizontal cells by excitatory amino acid neurotransmitter antagonists
Neuroscience Letters, 1982Membrane potentials of retinal horizontal cells have been recorded fro isolated fish retinae perfused with Ringer solutions containing various drugs. We show that glutamate diethyl ester (GDEE) and gamma-D-glutamylglycine (DGG), respectively antagonists of the excitatory neurotransmitter agonists quisqualate and kainate, hyperpolarize horizontal cells ...
J S, Rowe, K H, Ruddock
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The effects of excitatory amino acids and their antagonists on hippocampal electrophysiology
1984The role of excitatory acidic amino acids in synaptic transmission and the modulation of electrophysiological properties were examined in the hippocampal slice in vitro using conventional extracellular and intracellular recording techniques. Iontophoresis of L-glutamate, L-aspartate and the more potent and specific agonists N-methyl-DL-aspartate (NMA),
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Antagonists of Excitatory Amino Acid Receptors in the Treatment of Parkinson’s Disease
1994Recent progress in the connection anatomy of basal ganglia-thalamocortical circuits and in excitatory amino acid (EAA) research has provided new insights into possible pathophysiological mechanisms responsible for the appearance of the main symptoms in Parkinson’s disease (PD).
Paolo Del Dotto, Ubaldo Bonuccelli
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Excitatory amino acid antagonists and epilepsy
Biochemical Society Transactions, 1993Astrid G. Chapman, Brian S. Meldrum
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European Journal of Pharmacology, 1981
Both D(-)-and L(+)-2-amino-5-phosphonovaleric acid (APV) antagonize amino acid-induced excitations of mammalian spinal neurones and are qualitatively indistinguishable from D-alpha-aminoadipate in this respect. L(+)-APV however has a slower onset of action possibly suggesting that its affinity for the receptor is lower.
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Both D(-)-and L(+)-2-amino-5-phosphonovaleric acid (APV) antagonize amino acid-induced excitations of mammalian spinal neurones and are qualitatively indistinguishable from D-alpha-aminoadipate in this respect. L(+)-APV however has a slower onset of action possibly suggesting that its affinity for the receptor is lower.
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