Results 181 to 190 of about 9,081,085 (259)

Loose-patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1. [PDF]

Front Neurol
Nissen EM, Kirschstein T, Bertsche A, Köhling R, Franz D.   +4 more
europepmc   +1 more source

2D MXene‐Enabled Unidirectional Flexible Optoelectronic Memristor Toward Energy‐Efficient Neuromorphic Photosensing

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A transparent and flexible ITO/ZnO/TiO2/MXene optoelectronic memristor is developed via low‐temperature solution processing, exhibiting intrinsic self‐rectification and analog synaptic plasticity. The device enables wavelength‐selective photosynaptic response and multimodal learning behaviors, demonstrating strong potential for neuromorphic ...
Shoaib Anwer, Muhammad Umair Khan, Nada AbuHamra, Waqas Waheed, Mahmoud Al‐Qutayri, Baker Mohammad   +5 more
wiley   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels

Epilepsia, EarlyView.
β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi, John Williamson, Jhanvi Patel, Samikksha Kumar, Huayu Sun, Lucy Dang Nguyen, Katarzyna Rękawek, Ifrah Zawar, Jaideep Kapur   +8 more
wiley   +1 more source

Maternal Stress Primes Adolescent Stress Susceptibility via Microglial Complement-Dependent Synaptic Phagocytosis. [PDF]

Research (Wash D C)
Wang X, Jiang M, Wei L, Liang X, Fang F, Xie Y, Cang J.   +6 more
europepmc   +1 more source

Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition

Epilepsia, EarlyView.
Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga, Mercedes Pérez‐Fernández, Yuniesky Andrade‐Talavera, Benito Domínguez‐Velasco, Antonio Rodríguez‐Moreno, Manuel Álvarez‐Dolado   +5 more
wiley   +1 more source

Emulation of Synaptic Functions with Poly(Ionic Liquid) Heterojunction for Visual Pattern Recognition. [PDF]

ACS Nano
Balqis F, Lee JP, Xing Z, Wang H, Chen T, Ji R, Lee PS.   +6 more
europepmc   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in C9ORF72-frontotemporal dementia. [PDF]

Acta Neuropathol
Spillman AM, Alsop EB, Gittings LM, Garcia-Mansfield K, Piras I, Bonfitto A, Martinez MN, Sharma R, Preller KR, Huentelman M, Pirrotte P, Van Keuren-Jensen K, Sattler R.   +12 more
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source