Results 271 to 280 of about 141,800 (341)

Conflicting adaptations in an inhibitory feedback circuit

The Journal of Physiology, EarlyView.
Abstract figure legend We studied activity‐dependent adaptation in the fruit fly Drosophila’s memory centre, the mushroom body. Here, excitatory Kenyon cells (KCs) receive feedback inhibition from the anterior paired lateral (APL) neuron. When KCs are artificially overactivated for 24 h, both KCs and APL reduce their sensitivity to excitation (‘↓ Exc’,
Gregor A. Bergmann, Melissa W. Tan, Katie Greenin‐Whitehead, Philippe J. Fischer, Thomas C. Cozens, Andrew C. Lin   +5 more
wiley   +1 more source

A Narrative Review of Synaptic Transmission and Its Role in Neurological and Psychiatric Disorders: A Molecular Perspective. [PDF]

Cureus
Ahmed N, Rather HJ, Rana A, Vasim KA, Thaker KR, Tripathi D.   +5 more
europepmc   +1 more source

Synaptic Potentiation in Hippocampus by eEF2K Inhibitor A484954

Hippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT An important mechanism controlling protein synthesis is through phosphorylation of the eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K. Hyperphosphorylation of eEF2 is linked to many neuronal diseases characterized by cognitive impairments.
Qian Yang, Tian Li, Hannah M. Jester, Qiang Su, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma   +6 more
wiley   +1 more source

Neuron-Glioma Synapses in Tumor Progression. [PDF]

Biomedicines
Cueto-Ureña C, Ramírez-Expósito MJ, Martínez-Martos JM.   +2 more
europepmc   +1 more source

Metabolism Controls the Timing of Human Brain Development and Maturation

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Among primates the human brain is the largest in size, exhibiting a higher neuronal density and connectivity. The prolonged expansion and subsequent connectome reorganization of the human brain have been suggested to promote higher cognitive and behavioral abilities.
Valentina Rava, Erica Cannone, Maura Francolini, Elena Taverna   +3 more
wiley   +1 more source

The Neurexin1β Histidine-Rich Domain Is Involved in Excitatory Presynaptic Organization and Short-Term Plasticity. [PDF]

eNeuro
Feller B, Inagaki M, Wang M, Sivak A, Chofflet N, Takahashi H.   +5 more
europepmc   +1 more source

Intrinsically flexible multimode reconfigurable transistors for polymorphic circuits and neuromorphic devices. [PDF]

Nat Commun
Wang W, Qiu R, Zhu J, Zhu T, Wang J, Liu D, Liang J, Wang C, Zhang S, Wang Z, Huang Q, Wang X, Zhang M.   +12 more
europepmc   +1 more source

Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook. [PDF]

Front Psychiatry
Li C, Wang Z, Ye X, Lv J, Chen F, Zhang Y, Liu J, Li X, Duan J, Wang Y, Wang B, Tang W, Zhang J, Teng Y.   +13 more
europepmc   +1 more source

Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex. [PDF]

Cell Rep
Gutman-Wei AY, Sudarsanam S, Cabalinan AG, Shahid N, Shi A, Guzman-Clavel LE, Spindler-Krage SM, Agarwal A, Kolodkin AL, Brown SP.   +9 more
europepmc   +1 more source

Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex. [PDF]

Cereb Cortex
Vattino LG, Clayton KK, Hackett TA, Polley DB, Takesian AE.   +4 more
europepmc   +1 more source