Results 271 to 280 of about 408,389 (348)

Rare dysfunctional SCN2A variants are associated with malformation of cortical development

Epilepsia, Volume 66, Issue 3, Page 914-928, March 2025.
Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic variants in SCN2A are associated with a spectrum of neurodevelopmental disorders.
Jérôme Clatot, Christopher H. Thompson, Susan Sotardi, Jinan Jiang, Marina Trivisano, Simona Balestrini, D. Isum Ward, Natalie Ginn, Brunetta Guaragni, Laura Malerba, Angeliki Vakrinou, Mia Sherer, Ingo Helbig, Ala Somarowthu, Sanjay M. Sisodiya, Roy Ben‐Shalom, Renzo Guerrini, Nicola Specchio, Alfred L. George Jr, Ethan M. Goldberg   +19 more
wiley   +1 more source

Preferential superficial cortical layer activation during seizure propagation

Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.
Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya, Shinnosuke Shiono, Chengsan Sun, Edward Perez‐Reyes, Jaideep Kapur   +4 more
wiley   +1 more source

Fast activity chirp patterns in focal seizures from patients and animal models

Epilepsia, Volume 66, Issue 3, Page 621-631, March 2025.
Abstract Time–frequency analysis of focal seizure electroencephalographic signals performed with depth electrodes in human temporal lobe structures has revealed the occurrence at onset of oscillations at approximately 30–100 Hz that feature a monotonic rapid decay in frequency content.
Maxime Lévesque, Vadym Gnatkovsky, Fei Ran Li, Paolo Scalmani, Laura Uva, Massimo Avoli, Marco de Curtis   +6 more
wiley   +1 more source

Frequency‐specific alterations in brain connectivity induced by pulvinar stimulation

Epilepsia, EarlyView.
Abstract Objective Deep brain stimulation (DBS) is emerging as a promising therapy for patients with drug‐resistant epilepsy, particularly those who are either unsuitable for or unresponsive to resective surgery. The potential benefit of DBS in these patients may stem from its ability to reduce excessive brain functional connectivity (FC).
Emma Acerbo, Aude Jegou, Stanislas Lagarde, Francesca Pizzo, Julia Makhalova, Agnès Trébuchon, Christian‐George Bénar, Fabrice Bartolomei, Romain Carron   +8 more
wiley   +1 more source

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single‐nucleus multiomics

Epilepsia, EarlyView.
Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão, Manuela Lemoine, Ludmyla Kandratavicius, Clarissa L. Yasuda, Marina K. M. Alvim, Enrico Ghizoni, Ingmar Blümcke, Fernando Cendes, Fabio Rogerio, Iscia Lopes‐Cendes, Diogo F. T. Veiga   +10 more
wiley   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons

, 1998
Nathaniel N. Urban, Germán Barrionuevo
openalex   +1 more source

Estrogenic regulation of hippocampal inhibitory system across lifespan

Journal of Neuroendocrinology, EarlyView.
Abstract Estrogens produced in peripheral tissues and locally in the brain are potent neuromodulators. The function of the hippocampus, a brain region essential for episodic memory and spatial navigation, relies on the activity of ensembles of excitatory neurons whose activity is temporally and spatially coordinated by a wide diversity of inhibitory ...
Pablo Méndez, Rut de la Vega‐Ruiz, Alberto Montes‐Mellado   +2 more
wiley   +1 more source

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP‐producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re‐evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r.
Limei Zhang, Vito Salvador Hernández, Mario Alberto Zetter, Oscar Rene Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Lee E. Eiden, Robert P. Millar   +7 more
wiley   +1 more source

Recording of excitatory postsynaptic potentials after tonic stimulation from hybrid neural circuit

, 2018
Albina Lebedeva
openalex   +2 more sources