3-Nitrotyrosine activates excitatory interneurons by inhibiting GABA receptors in the rat spinal dorsal horn. [PDF]
Kaimochi Y +9 more
europepmc +1 more source
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić +4 more
wiley +1 more source
Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality. [PDF]
Estarellas C +8 more
europepmc +1 more source
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti +6 more
wiley +1 more source
Exposure to β-hydroxybutyrate reduces the operating set point and increases excitability in hippocampal circuitry of healthy mice. [PDF]
Zampieri TT +11 more
europepmc +1 more source
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova +6 more
wiley +1 more source
An integrated <i>i</i> <i>n vitro</i> platform and biophysical modeling approach for studying synaptic transmission in isolated neuronal pairs. [PDF]
Amos G +10 more
europepmc +1 more source
Early adversity and the comorbidity between metabolic disease and psychopathology
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas +1 more
wiley +1 more source
Cholesterol depletion inhibits BDNF-dependent spike timing-dependent plasticity at thalamo-amygdala synapses. [PDF]
Munsch T, Meis S, Lessmann V.
europepmc +1 more source
Amacrine cell inputs to OFF midget ganglion cells in macaque retina
Abstract figure legend The goal of this study was to explain the findings from physiological studies that OFF midget ganglion cells had larger receptive field centers than expected from their dendritic field diameters. First, we confirmed that OFF mRGCs (OFF MGC) receive input from diffuse bipolar cells (DB) as well as OFF midget bipolar cells (FMB ...
David W. Marshak +8 more
wiley +1 more source

