Results 231 to 240 of about 72,565 (297)

Single‐nucleus RNA sequencing reveals ferroptosis as a potential contributor to the pathogenesis of focal cortical dysplasia

open access: yesClinical and Translational Medicine, Volume 16, Issue 5, May 2026.
1. A single‐cell analysis was conducted to investigate the transcriptomic changes in cells within focal cortical dysplasia (FCD). 2. Ferroptosis may play a significant role in the pathogenesis of FCD, potentially contributing to cellular damage and epileptogenesis. 3.
Qingyang Zeng   +10 more
wiley   +1 more source

Excitatory neurons and astrocytes‐specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single‐cell spatial transcriptomics

open access: yesClinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang   +9 more
wiley   +1 more source

The Role of Plasticity in Replay: Stability Through Anti‐Hebbian Rules

open access: yesHippocampus, Volume 36, Issue 3, May 2026.
ABSTRACT Hippocampal replay is now considered to be a cornerstone of memory consolidation, yet the synaptic plasticity rules governing its dynamics remain elusive. Under the standard asymmetric Hebbian spike‐timing dependent plasticity (STDP) model, the same spike patterns that promote activity propagation along one direction of sequential activation ...
Lior Baron   +2 more
wiley   +1 more source

Layer V Neocortical neurons from individuals With drug-resistant epilepsy show multiple synaptic alterations but lack somatic hyperexcitability. [PDF]

open access: yesPLoS One
Márquez LA   +8 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy