Results 31 to 40 of about 72,565 (297)

Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons [PDF]

Proceedings of the National Academy of Sciences, 1998
The manner in which the thousands of synaptic inputs received by a pyramidal neuron are summed is critical both to our understanding of the computations that may be performed by single neurons and of the codes used by neurons to transmit information. Recent work on pyramidal cell dendrites has shown that subthreshold synaptic inputs are modulated by ...
N N, Urban, G, Barrionuevo
openaire   +2 more sources

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source

SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities

Cell Death and Disease, 2022
Aberrantly synchronized neuronal discharges in the brain lead to epilepsy, a devastating neurological disease whose pathogenesis and mechanism are unclear.
Yanke Zhang, Junhong Wu, Yin Yan, Yixue Gu, Yuanlin Ma, Min Wang, Hui Zhang, Kaiyan Tao, Yang Lü, Weihua Yu, Wei Jing, Xuefeng Wang, Xin Tian   +12 more
doaj   +1 more source

Membrane resonance enables stable and robust gamma oscillations [PDF]

, 2012
Neuronal mechanisms underlying beta/gamma oscillations (20-80 Hz) are not completely understood. Here, we show that in vivo beta/gamma oscillations in the cat visual cortex sometimes exhibit remarkably stable frequency even when inputs fluctuate ...
Moca, Vasile V., Mureşan, Raul C., Nikolić, Danko, Singer, Wolf   +3 more
core   +1 more source

Analogue signaling of somatodendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons

eLife, 2023
Axons are equipped with the digital signaling capacity by which they generate and faithfully propagate action potentials (APs), and also with the analogue signaling capacity by which subthreshold activity in dendrites and soma is transmitted down the ...
Federico Trigo, Shin-ya Kawaguchi
doaj   +1 more source

Complex events initiated by individual spikes in the human cerebral cortex.

PLoS Biology, 2008
Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and
Gábor Molnár, Szabolcs Oláh, Gergely Komlósi, Miklós Füle, János Szabadics, Csaba Varga, Csaba Varga, Pál Barzó, Gábor Tamás   +8 more
doaj   +1 more source

Dynamic causal models and physiological inference: a validation study using isoflurane anaesthesia in rodents.

PLoS ONE, 2011
Generative models of neuroimaging and electrophysiological data present new opportunities for accessing hidden or latent brain states. Dynamic causal modeling (DCM) uses Bayesian model inversion and selection to infer the synaptic mechanisms underlying ...
Rosalyn J Moran, Fabienne Jung, Tetsuya Kumagai, Heike Endepols, Rudolf Graf, Raymond J Dolan, Karl J Friston, Klaas E Stephan, Marc Tittgemeyer   +8 more
doaj   +1 more source

Essential Functions of the Transcription Factor Npas4 in Neural Circuit Development, Plasticity, and Diseases

Frontiers in Neuroscience, 2020
Signaling from the synapse to nucleus is mediated by the integration and propagation of both membrane potential changes (postsynaptic potentials) and intracellular second messenger cascades.
Jian Fu, Ouyang Guo, Zhihang Zhen, Junli Zhen   +3 more
doaj   +1 more source

Effect of Alpha 1-Adrnoceptor Antagonists on Postsynaptic Sensitivity in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats Using Slice Patch-Clamp Technique for mEPSC [PDF]

International Neurourology Journal, 2020
Purpose Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms (LUTS). However, the mechanism of action of these compounds remains unclear.
Daisuke Uta, Tsuyoshi Hattori, Megumu Yoshimura   +2 more
doaj   +1 more source

New insights into the mechanisms and sites of action of lamotrigine [PDF]

, 2000
This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs.
Grunze, Heinz, Langosch, J. M., Walden, Jörg, Zhou, X. Y.   +3 more
core   +1 more source