Results 231 to 240 of about 83,508 (337)

Age dependent seizure susceptibility of CA2 hippocampal neurons. [PDF]

Front Cell Neurosci
Correa J, Sablani S, Wasfi M, Correa C, Bandelow S.   +4 more
europepmc   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, Volume 13, Issue 5, 27 January 2026.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Patterns of altered in vivo brain metabolism in patients with amyotrophic lateral sclerosis (ALS) and asymptomatic C9orf72 mutation carriers: a cross-sectional ¹H and ³¹P magnetic resonance spectroscopic 7T imaging study. [PDF]

EBioMedicine
Westeneng HJ, Nitert AD, van Veenhuijzen K, Wismans C, Donatelli G, Tan HHG, van Hoek W, van Es MA, Klomp DWJ, Bhogal AA, Veldink JH, Wijnen JP, van den Berg LH.   +12 more
europepmc   +1 more source

PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning

, 2015
Timothy Johanssen, Nuttawat Suphantarida, Paul S. Donnelly, Xiang M. Liu, Steven Petrou, Andrew F. Hill, Kevin J. Barnham   +6 more
openalex   +2 more sources

Improving Kv7 targeting anticonvulsants ‐ will repurposing save the day?

British Journal of Pharmacology, Volume 183, Issue 3, Page 435-437, February 2026.
Nikita Gamper
wiley   +1 more source

mGluR5 as a Potential Orchestrator of Astrocyte Interactions in Neurological Disorders. [PDF]

Neural Plast
Kim J, Lee J, Song H, Koo JW, Kang S.
europepmc   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

Parechovirus-3 infection disrupts immunometabolism and leads to glutamate excitotoxicity in neural organoids. [PDF]

Cell Mol Life Sci
Capendale PE, Ambikan AT, García-Rodríguez I, de Sá RV, Pajkrt D, Wolthers KC, Neogi U, Sridhar A.   +7 more
europepmc   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights. [PDF]

Int J Mol Sci
Nuthalapati P, Holmes SE, Altalib HH, Fesharaki-Zadeh A.   +3 more
europepmc   +1 more source