Results 231 to 240 of about 95,867 (358)

Exhaustive exercise abolishes REV‐ERB‐α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Acute exhaustive exercise (EE) reduces REV‐ERB‐α protein levels in skeletal muscle, which impairs its transcriptional repression of kynurenine (KYN) 3‐monooxygenase (KMO), a key enzyme in the KYN pathway that converts KYN into potentially neurotoxic metabolites, collectively referred to as ‘kynurenines’. This study identifies KMO
Alisson Luiz da Rocha, Ana Paula Pinto, Ivo Vieira de Sousa Neto, Vitor Rosetto Muñoz, Bruno Brieda Marafon, Lilian Eslaine Costa Mendes da Silva, José Rodrigo Pauli, Dennys Esper Cintra, Eduardo Rochete Ropelle, Fernando Moreira Simabuco, Leandro Pereira de Moura, Ellen Cristini de Freitas, Donato Americo Rivas, Adelino Sanchez Ramos da Silva   +13 more
wiley   +1 more source

Mapping key trends, relationships, and molecular pathways for neuroprotection in glaucoma: a bibliometric approach. [PDF]

Int J Ophthalmol
Agarwal P, Agarwal R, Iezhitsa I.
europepmc   +1 more source

Temporal Interference Stimulation: Mechanisms, Optimization, Validation, and Clinical Prospects—A Comprehensive Review

WIREs Computational Statistics, Volume 17, Issue 3, September 2025.
This schematic highlights the key developments discussed in this review paper on Temporal Interference Stimulation (TIS), a non‐invasive technique for deep brain stimulation using interfering high‐frequency electric fields. Topics include optimization strategies, computational modelling, experimental findings, comparisons with other neuromodulation ...
Hossein Soroushi, Sara Abbasi, Yun Du, Ning Ning, Yuming Lei   +4 more
wiley   +1 more source

Astrocytes Regulate N-Methyl-d-aspartate Receptor Subunit Composition Increasing Neuronal Sensitivity to Excitotoxicity [PDF]

, 2001
Maki Daniels, David R. Brown
openalex   +1 more source

Immunoexcitoxicity as the possible major pathophysiology behind multiple sclerosis and other autoimmune disorders. [PDF]

Surg Neurol Int
Blaylock RL.
europepmc   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Differential postreceptor signaling events triggered by excitotoxic stimulation of different ionotropic glutamate receptors in retinal neurons [PDF]

, 2001
Armanda E. Santos, Ana Luı́sa Carvalho, María Celeste Lopes, Arsélio P. Carvalho   +3 more
openalex   +1 more source

Editorial: Environmental clues to brain disease

Frontiers in Aging Neuroscience, 2023
Patrizia Giannoni, Federica Bertaso, Gustavo Provensi   +2 more
doaj   +1 more source

How to Pick a Neuroprotective Drug in Stroke Without Losing Your Mind? [PDF]

Life (Basel)
Tauskela JS, Blondeau N.
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, Volume 47, Issue 7, July 2025.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source