Results 241 to 250 of about 82,251 (326)

Lack of kainic acid‐induced gamma oscillations predicts subsequent CA1 excitotoxic cell death

, 2009
Seiichiro Jinde, Juan E. Belforte, Kazu Nakazawa, J. Yamamoto, Matthew Wilson, Susumu Tonegawa   +5 more
openalex   +2 more sources

Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage

Glia, Volume 73, Issue 12, Page 2386-2406, December 2025.
Main Points NBCe1 is upregulated in reactive astrocytes following ischemic stroke. Deletion of astrocytic Nboe1 reduces stroke volume, preserves AQP4 polarization, reduces BBB permeability, and improves neurological function after ischemic stroke. ABSTRACT The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in ...
Okan Capuk, Elise Berthold, Kathiravan Kaliyappan, Mansi Avunoori, Rajesh Muduganti, Sanjana Krishna, Shamseldin Metwally, Mary McFarland, Shanshan Song, Victoria Fiesler, Sydney Fischer, Lesley M. Foley, T. Kevin Hitchens, Susannah Waxman, Ian A. Sigal, Shefeeq M. Theparambil, Gulnaz Begum   +16 more
wiley   +1 more source

NMDA Receptor: An Old but Refreshed Target for Neurodegeneration. [PDF]

NeuroSci
Marques JM, Rodrigues RJ.
europepmc   +1 more source

Neuronal apoptosis in excitotoxicity : involvement of nitric oxide and cytoskeletal damage

, 1996
Emanuela Bonfoco
openalex  

Dysbiosis and Therapeutic Modulation of the Gut Microbiota in Multiple Sclerosis: A Narrative Review

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Multiple sclerosis (MS) is a persistent autoimmune disease that affects the central nervous system. The etiology of MS is complex, involving a variety of genetic and environmental factors. Mounting evidence suggests that dysbiosis significantly impacts the progression of MS mainly through its direct effects upon the immune ...
Mojtaba Memariani, Hamed Memariani
wiley   +1 more source

Upregulation of GLT-1 Expression Attenuates Neuronal Apoptosis and Cognitive Dysfunction via Inhibiting the CB1-CREB Signaling Pathway in Mice with Traumatic Brain Injury. [PDF]

Biomolecules
Bu B, Ma R, Wang C, Jiang S, Xu X.
europepmc   +1 more source

Non‐canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis

, 2018
K. Genevieve Feldmann, Ayesha Chowdhury, Jessica L. Becker, N’Gina McAlpin, Taqwa Ahmed, Syed Haider, Jian X. Richard Xia, Karina Diaz, Monal Mehta, Itzhak Mano   +9 more
openalex   +2 more sources

Research progress of neurovascular units involved in ischemic stroke

Ibrain, Volume 11, Issue 4, Page 492-503, Winter 2025.
The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang, Hao Tong, Zhuo‐Fan Ye, Zu‐Cai Xu, Tao Tao   +4 more
wiley   +1 more source

DYRK1A in the physiology and pathology of the neuron-astrocyte axis. [PDF]

Front Neurosci
Cisternas P, Kim J, Ashfeld B, Zartman J.   +3 more
europepmc   +1 more source

Glutamate Exacerbates Traumatic Brain Injury‐Induced Acute Lung Injury Through NMDAR/ROS/Ca2+ Signaling Pathway in Pulmonary Endothelial Cells

The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 12, December 2025.
ABSTRACT Traumatic brain injury (TBI) causes a high level of blood glutamate, which triggers host defense by activating oxidative stress and inflammation response. However, the concrete mechanism underlying its exacerbating effects on acute lung injury (ALI) severity remains unknown.
Song Zhou, Ying‐Ying Lou, Xue‐Zhen Ying   +2 more
wiley   +1 more source