Results 241 to 250 of about 83,508 (337)

Bioinspired Engineering beyond Homeostasis

Advanced Intelligent Systems, Volume 8, Issue 1, January 2026.
This perspective article introduces systems biology as the unifying theoretical framework behind bioinspired engineering. As an example, it explores how disruptions in multiscale biological systems, associated with pathological states, can be viewed as localized failure modes of biological cooperation showing emergent advantages that can inspire ...
Rosalia Moreddu
wiley   +1 more source

Reduction of the Ca²⁺ permeability of ligand-gated ion channels as a strategy against excitotoxicity. [PDF]

Front Cell Neurosci
D'Andrea T, Fucile S.
europepmc   +1 more source

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex‐specific alteration of multiple proteins involved in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION In Alzheimer's disease (AD), females have higher prevalence and faster progression, but sex‐specific molecular findings in AD are limited. METHODS We comprehensively examined 6162 proteins in cerebrospinal fluid (CSF) from 2496 participants to identify sex‐specific proteomic alteration by CSF amyloid beta (Aβ)42 and phosphorylated
Anh N. Do, Soomin Song, Muhammad Ali, Jigyasha Timsina, Lihua Wang, Daniel Western, Menghan Liu, Jessie Sanford, Matitee Rosende‐Roca, Merce Boada, Raquel Puerta, Edward N. Wilson, Agustin Ruiz, Pau Pastor, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Tony Wyss‐Coray, Carlos Cruchaga, Yun Ju Sung   +17 more
wiley   +1 more source

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases-an update. [PDF]

Acta Pharmacol Sin
Wu WL, Gong XX, Qin ZH, Wang Y.
europepmc   +1 more source

Current Concepts of Excitotoxicity [PDF]

Journal of Neuropathology and Experimental Neurology, 1996
openaire   +2 more sources

Blood‐based Alzheimer's disease biomarkers and cognitive trajectories in older people with HIV with undetectable viral loads

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Cognitive impairment among people with HIV (PWH) remains common, yet underlying mechanisms remain unclear. Alzheimer's disease (AD) is the leading cause of dementia, and blood‐based biomarkers offer a promising diagnostic alternative.
Akarin Hiransuthikul, Poosanu Thanapornsangsuth, Watayuth Luechaipanit, Thanaporn Haethaisong, Sasiwimol Ubolyam, Tanakorn Apornpong, Win Min Han, Stephen Kerr, Anchalee Avihingsanon, HIV‐NAT 006 and 207 study team   +9 more
wiley   +1 more source

Neuroprotective effects of ceftriaxone after severe traumatic brain injury in male rats: a behavioral, biochemical, and histological study. [PDF]

Ann Med Surg (Lond)
Esfahani A, Siahposht-Khachaki A, Talebpour Amiri F, Emami Meybodi T, Gheibi M, Ghadirzadeh E, Biabani M, Taghipour G, Safarbalou A, Farzin D.   +9 more
europepmc   +1 more source

Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION It is unknown if neurodegeneration trajectories differ between Down syndrome (DS) and autosomal dominant Alzheimer's disease (ADAD), both of which are genetic forms of Alzheimer's disease (AD). METHODS We compared brain volumes in DS, ADAD, and unaffected family members serving as controls.
James T. Kennedy, Julie K. Wisch, Anna H. Boerwinkle, Peter R. Millar, Nicole S. McKay, Adam M. Brickman, Jasmeer P. Chhatwal, Patricio Chrem Mendez, Bradley T. Christian, Anne Cohen, Carlos Cruchaga, Alisha Daniels, Shaney Flores, Benjamin L. Handen, Sigan L. Hartley, Elizabeth Head, Laura Ibanez, Sharon J. Krisnsky‐McHale, Christian la Fougere, Florence Lai, Charles M. Laymon, Joseph H. Lee, Jae‐Hong Lee, Johannes Levin, Jorge Llibre‐Guerra, David F. Aguillon, Ira T. Lott, Mark Mapstone, Eric McDade, John Morris, Sid E. O'Bryant, Julie C. Price, Michael S. Rafii, Jee Hoon Roh, H. Diana Rosas, Nicole Schupf, Charlene Supnet‐Bell, Chengjie Xiong, Shahid Zaman, Tammie L. S. Benzinger, Brian A. Gordon, Beau M. Ances, the Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network   +43 more
wiley   +1 more source