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TRP Channels in Excitotoxicity
The NeuroscientistGlutamate excitotoxicity is a central mechanism contributing to cellular dysfunction and death in various neurological disorders and diseases, such as stroke, traumatic brain injury, epilepsy, schizophrenia, addiction, mood disorders, Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, pathologic pain, and even normal ...
Pengyu Zong +3 more
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2014
In this section, it will be studied how excitotoxicity contributes to neurodegeneration in the context of multiple sclerosis (MS). MS has long been regarded as an autoimmune inflammatory disease targeting oligodendrocytes of the central nervous system (CNS). However, recent advancement in research questioned whether MS is merely an inflammatory disease
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In this section, it will be studied how excitotoxicity contributes to neurodegeneration in the context of multiple sclerosis (MS). MS has long been regarded as an autoimmune inflammatory disease targeting oligodendrocytes of the central nervous system (CNS). However, recent advancement in research questioned whether MS is merely an inflammatory disease
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Wernicke’s encephalopathy: an excitotoxicity hypothesis
Metabolic Brain Disease, 1997Thiamine deficiency is a recognized cause of Wernicke's encephalopathy (WE), a condition in which small necrotic lesions are found in close proximity to the third and fourth ventricles and the Sylvian aqueduct. Although the neuropathology of WE is well-established, the pathogenic mechanisms that determine the formation and distribution of brain lesions
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Glutamate-Mediated Excitotoxicity
1999Excitotoxicity — the ability of glutamate receptor activation to trigger neuronal cell death — has been recognized for more than four decades (Lucas and New-house 1957; Olney 1969; Choi 1988b). Over the last 10–15 years, there has been an accumulation of evidence that suggests that glutamate toxicity contributes to brain or spinal cord tissue damage in
Dennis W. Choi +2 more
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Excitotoxicity, apoptosis and neuropsychiatric disorders
Current Opinion in Pharmacology, 2003In recent decades there has been an upsurge of interest in mechanisms of cell death in the central nervous system. Much attention has been focused on two cell death processes - excitotoxicity and apoptosis - and much confusion has arisen regarding how one relates to the other, and how either relates to neurological disorders.
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CELL DAMAGE/EXCITOTOXICITY | Excitotoxicity and Neurodegenerative Disease
2009Tannenberg, R. K., Dodd, P. R.
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