Results 261 to 270 of about 83,508 (337)

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies. [PDF]

Front Aging Neurosci
Zhang K, Wen M, Nan X, Zhao S, Li H, Ai Y, Zhu H.   +6 more
europepmc   +1 more source

BETMB: A Dual‐Target Compound for Synergistic Suppression of Neuronal Hyperexcitability in Refractory Epilepsy via Concurrent Modulation of Nav Channels and GABAA Receptors

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
BETMB exerts multi‐target effects by positively modulating GABAARs and blocking NaV channels in a state‐dependent manner. This suppresses neuronal hyperexcitability, leading to seizure control and restoration of cognitive function. ABSTRACT Aims This study aims to evaluate 5‐(but‐1‐en‐1‐yl)‐1,2,3‐trimethoxybenzene (BETMB) as a novel dual‐target anti ...
Di Zhang, Kai Li, Yingying Zhang, Yao Nie, Yue Li, Rui Li, Xin Wang, Shengjun Mao   +7 more
wiley   +1 more source

Hops (<i>Humulus lupulus</i>) Extract Enhances Redox Resilience and Attenuates Quinolinic Acid-Induced Excitotoxic Damage in the Brain. [PDF]

Nutrients
Ortega DR, Hernández Pérez ER, Gutiérrez Magdaleno M, Meza-Sosa KF, Pineda Calderas L, Álvarez Silva MJ, Vázquez Cervantes GI, González Esquivel DF, González Alfonso WL, Navarro Cossio JA, Ovalle Rodríguez P, Flores I, Salazar A, Gómez-Manzo S, Pineda B, Pérez de la Cruz V.   +15 more
europepmc   +1 more source

Anti‐Neuroinflammation Activity of Essential Oils and Fatty Acids

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Neuroinflammation plays a pivotal role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Current pharmacological interventions, such as NSAIDs and corticosteroids, are limited by systemic toxicity and insufficient efficacy in targeting chronic neuroinflammatory processes.
Zelong Jin, Yige Song, Ahmed Attia Ahmed Abdelmoaty, Feng Lin, Jiujun Li, Xianyang Chen   +5 more
wiley   +1 more source

Kynurenine Pathway Metabolites as Mediators of Exercise-Induced Mood Enhancement, Fatigue Resistance, and Neuroprotection. [PDF]

Int J Mol Sci
Tero-Vescan A, Ștefănescu R, Pușcaș A, Buț M, Ősz BE, Slevin M.   +5 more
europepmc   +1 more source

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Bromelain Restores Glutamatergic Homeostasis via Regulation of NR2A, GLT-1, EAAC1, and xCT in Arsenic-Induced Cerebral Cortex and Hippocampal Neurotoxicity. [PDF]

F1000Res
Emeka Godson A, Chinua Ogonnadi K, Uchenna Agu A, Johnson Nto N, Aniaku I, Yvonne Nwabueze Y, Onyinye Ojiakor V, Chinyere Nkemjika A.   +7 more
europepmc   +1 more source

Altered Inflammatory Signature in a C9ORF72 ‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, Volume 74, Issue 1, January 2026.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Toward a Unified Framework in Molecular Neurobiology of Alzheimer's Disease: Revisiting the Pathophysiological Hypotheses. [PDF]

Mol Neurobiol
Hein ZM, Karikalan B, Gopalakrishna PK, Dhevi K, Alkatiri A, Hussan F, Mohd Moklas MA, Jagadeesan S, Che Ramli MD, Che Mohd Nassir CMN, Vishnumukkala T.   +10 more
europepmc   +1 more source