Results 261 to 270 of about 82,251 (326)

Telomerase Depletion Accelerates Ageing of the Zebrafish Brain

Aging Cell, Volume 24, Issue 12, December 2025.
Telomerase depletion accelerates markers of ageing in the zebrafish brain, ranging from dysregulated immune and stress ageing transcriptomic hallmarks to in situ accumulation of senescence‐associated markers and inflammation, dysfunction of the blood–brain barrier and increased anxiety behaviour.
Raquel R. Martins, Savandara Besse, Pam S. Ellis, Rabia Sevil, Naomi Hartopp, Catherine Purse, Georgia Everett‐Brown, Owain Evans, Nadiyah Mughal, Mina H. F. Wahib, Zerkif Yazigan, Samir Morsli, Ada Jimenez‐Gonzalez, Andrew Grierson, Heather Mortiboys, Chrissy Hammond, Michael Rera, Catarina M. Henriques   +17 more
wiley   +1 more source

Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Parkinson's disease (PD) involves the progressive death of dopamine‐secreting neurons. This research investigates the neuroprotective role of the pharmacological inhibition of phosphodiesterases (PDE) by Ibudilast. This drug elevates levels of the signaling molecule cAMP, which boosts the production of GDNF, a potent neuroprotective factor naturally ...
Xavier d’Anglemont de Tassigny, Alejandro Jiménez‐Medina, Ivette López‐López, José López‐Barneo   +3 more
wiley   +1 more source

Factors Contributing to Resistance to Ischemia-Reperfusion Injury in Olfactory Mitral Cells. [PDF]

Int J Mol Sci
Lee CH, Ahn JH, Won MH.
europepmc   +1 more source

Eye‐Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Eye‐targeted A20 gene therapy alleviates ischemic retinopathy by limiting pathologic neovascularization, reducing gliosis, and protecting from neuronal apoptosis. ABSTRACT Intravitreal administration of anti‐VEGF therapies has been highly beneficial in treating ischemic proliferative retinopathies (PR).
Sanah Essayagh, Tarek Aridi, Tytteli Turunen, Lynn Choi, Hugo Adam, Nyah Patel, Salvatore T. Scali, Mark D. Fisher, Karl Skaf, Eva Csizmadia, Phillip Brennan, Anthony Sadek, Jona Skaf, Michelle Zhan, Emily Hansen, Maryam Shamloo, Nicholas R. DeStefino, Allen C. Clermont, Cleide Angolano, Christiane Ferran   +19 more
wiley   +1 more source

Evaluation of a New Riluzole-Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH-SY5Y- Derived Neurons. [PDF]

J Neurochem
Cazzola J, Talpo F, Faravelli G, Donati C, Maramai S, Saletti M, Giuliani G, Paolino M, Cappelli A, Anzini M, Sommi P, Vitali A, Sala A, Trucco A, Biella GR, Spaiardi P.   +15 more
europepmc   +1 more source

Targeting CAPON to modulate the CAPON-NOS Axis: a computational approach. [PDF]

Comput Struct Biotechnol J
Nada H, Wolber G, Gabr MT.
europepmc   +1 more source

Organophosphate Chemical Nerve Agents, Oxidative Stress, and NADPH Oxidase Inhibitors: An Overview. [PDF]

Int J Mol Sci
Meyer C, Thippeswamy T.
europepmc   +1 more source

A brain-accessible peptide modulates stroke inflammatory response and neurotoxicity by targeting BDNF-receptor TrkB-T1 specific interactome. [PDF]

Theranostics
Ugalde-Triviño L, Tejeda GS, Esteban-Ortega GM, Díaz-Guerra M.   +3 more
europepmc   +1 more source

Mito-Apocynin Protects Against Kainic Acid-Induced Excitotoxicity by Ameliorating Mitochondrial Impairment. [PDF]

Mol Neurobiol
Lin M, Wu H, Wan X, Liu N, Jiang Y, Sheng Y, Wang J, Xu H, Xue J, Qin Z, Wang Y.   +10 more
europepmc   +1 more source

CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX‐2 Activity and Oxidative Stress

Ataúlfo Martínez‐Torres, Julio Morán   +1 more
openalex   +1 more source