Results 1 to 10 of about 337,234 (319)

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

open access: yesFrontiers in Pharmacology, 2021
Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to limit its development.
Pengfei Li   +10 more
doaj   +1 more source

Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011

open access: yesFrontiers in Cell and Developmental Biology, 2022
PPI-1011 is a synthetic plasmalogen precursor in development as a treatment for multiple plasmalogen-deficiency disorders. Previous work has demonstrated the ability of PPI-1011 to augment plasmalogens and its effects in vitro and in vivo, however, the ...
Tara Smith   +2 more
doaj   +1 more source

Emergence of sector and spiral patterns from a two-species mutualistic cross-feeding model [PDF]

open access: yesPLoS ONE 17(10): e0276268 (2022), 2022
The ubiquitous existence of microbial communities marks the importance of understanding how species interact within the community to coexist and their spatial organization. We study a two-species mutualistic cross-feeding model through a stochastic cellular automaton on a square lattice using kinetic Monte Carlo simulation.
arxiv   +1 more source

Properties of the accretion ring in an X-ray binary, and accretion and excretion two-layer flows from it [PDF]

open access: yes, 2021
We study properties of an accretion ring in a steady mass flow from a companion star to a compact object in an X-ray binary. The accretion ring is a place where matter inflowing from a companion star sojourns for a while to bifurcate to accretion and excretion flows due to angular momentum transfer in it.
arxiv   +1 more source

Accretion environments of active galactic nuclei [PDF]

open access: yes, 2021
We study accretion environments of active galactic nuclei when a super-massive black hole wanders in a circum-nuclear region and passes through an interstellar medium there. It is expected that a Bondi-Hoyle-Lyttleton type accretion of the interstellar matter takes place and an accretion stream of matter trapped by the black hole gravitational field ...
arxiv   +1 more source

Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157, a potential drug for treating various wounds, in rats and dogs

open access: yesFrontiers in Pharmacology, 2022
Body-protective compound (BPC) 157 demonstrates protective effects against damage to various organs and tissues. For future clinical applications, we had previously established a solid-phase synthesis process for BPC157, verified its biological activity ...
Lei He   +16 more
doaj   +1 more source

Phosphorus recycling from human excreta in French agroecosystems and potential for food self-sufficiency [PDF]

open access: yes, 2023
Phosphorus (P) is an essential constituent of life but large P losses from agroecosystems and sanitation systems are a major source of eutrophication in water bodies.These losses are doubly detrimental as P in human excretions can be used for crop fertilization.Through a unique dataset of 20,000 French WasteWater Treatment Plants (WWTPs) operational ...
arxiv   +1 more source

Mass flows and their behaviors in the SS433--W50 system [PDF]

open access: yes, 2022
We propose the scenario to interpret the overall observational features of the SS433--W50 system. The most unique features of SS433 are the presence of the precessing, mildly relativistic jets and the obscuration of the central engine, which are considered to be due to a supercritical accretion on to the central compact object.
arxiv   +1 more source

Comparing the Ecological Stoichiometry in Green and Brown Food Webs – A Review and Meta-analysis of Freshwater Food Webs

open access: yesFrontiers in Microbiology, 2017
The framework of ecological stoichiometry was developed primarily within the context of “green” autotroph-based food webs. While stoichiometric principles also apply in “brown” detritus-based systems, these systems have been historically understudied and
Michelle A. Evans-White   +1 more
doaj   +1 more source

A Rapid LC-MS/MS Method for Simultaneous Determination of Ten Flavonoid Metabolites of Naringin in Rat Urine and Its Application to an Excretion Study

open access: yesFoods, 2022
Naringin is a dietary flavonoid glycoside with multiple bioactivities. It has been involved in numerous metabolism and excretion studies, and its metabolic properties are clear.
Xuan Zeng   +4 more
doaj   +1 more source

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