Results 1 to 10 of about 622,707 (285)

Pharmacokinetics, Tissue Distribution and Excretion of Demethyleneberberine, a Metabolite of Berberine, in Rats and Mice

open access: yesMolecules, 2023
Demethyleneberberine is an active component extracted from the Chinese herbal drug Cortex Phellodendri. It is also a metabolite of berberine in animals and humans.
Jingqi Li   +4 more
doaj   +1 more source

Pharmacokinetics, bioavailability, and excretion of ponazuril in piglets

open access: yesFrontiers in Veterinary Science, 2022
Ponazuril is a triazine anticoccidial drug which is the main metabolite of toltrazuril in animals, it has excellent activity against many protozoa, including Cystoisospora suis, and has broad application prospects in the control of swine coccidiosis.
Wenxiang Wang   +10 more
doaj   +1 more source

Exploring the potential hazard of Mycobacterium avium subspecies paratuberculosis as a cause for Crohn's disease [PDF]

open access: yesVeterinary World, 2017
Background: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease (JD), or paratuberculosis in ruminants has been suspected to be implicated in the pathogenesis of Crohn's disease (CD) in humans with chronic ...
Sukumar Bharathy   +2 more
doaj   +1 more source

Pharmacokinetics, absorption, distribution, metabolism and excretion of the MEK inhibitor zapnometinib in rats

open access: yesFrontiers in Pharmacology, 2022
Zapnometinib is a MEK inhibitor currently under clinical development for the treatment of COVID-19 and influenza. Zapnometinib has both antiviral and immunomodulatory effects. Information concerning the absorption, distribution, metabolism, and excretion
Yvonne Füll   +5 more
doaj   +1 more source

Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1

open access: yesFrontiers in Pharmacology, 2021
The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane.
Giuliano Ciarimboli
doaj   +1 more source

Sugar intake among German adolescents: trends from 1990-2016 based on biomarker excretion in 24-h urine samples [PDF]

open access: yes, 2020
Trend analyses based on dietary records suggest decreases in the intakes of total (TS), added (AS) and free sugar (FS) since 2005 among children and adolescents in Germany. In terms of age trends, TS intake decreased with increasing age.
Alexy, Ute   +5 more
core   +1 more source

PHARMACOKINETIC PROPERTIES OF A NEW KAPPA-OPIOID ANALGESIC RU-1205 COMPOUND AT A SINGLE PERORAL ADMINISTRATION

open access: yesФармация и фармакология (Пятигорск), 2021
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between its ...
A. A. Spasov   +8 more
doaj   +1 more source

Measurement of Fecal Testosterone Metabolites in Mice: Replacement of Invasive Techniques [PDF]

open access: yes, 2020
Testosterone is the main reproductive hormone in male vertebrates and conventional methods to measure testosterone rely on invasive blood sampling procedures.
Auer, Kerstin E.   +5 more
core   +1 more source

Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness

open access: yesFrontiers in Pharmacology, 2020
Paeonol is a major bioactive ingredient in Moutan Cortex (the root barks of Paeonia suffruticosa Andrews) and exhibited a wide range of bioactivities such as anti-inflammation, anti-oxidation, hypoglycemic effect, analgesic, and others.
Xintong Hu   +14 more
doaj   +1 more source

Urinary porphyrin excretion in hepatitis C infection [PDF]

open access: yes, 1999
A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism.
Jacob, Karl   +2 more
core   +1 more source

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