Results 11 to 20 of about 337,234 (319)

Fate of Ingested Aristolactams from Aristolochia chilensis in Battus polydamas archidamas (Lepidoptera: Papilionidae)

open access: yesInsects, 2013
We performed a sequestration study of aristolactams (ALs) from Aristolochia chilensis in Battus polydamas archidamas (Lepidoptera: Papilionidae) by examining the AL content of the plant, fifth instar larvae, osmeterial secretion, pupae, exuviae and feces.
Angel Olguín   +2 more
doaj   +1 more source

The Biological Fate of Pharmaceutical Excipient β-Cyclodextrin: Pharmacokinetics, Tissue Distribution, Excretion, and Metabolism of β-Cyclodextrin in Rats

open access: yesMolecules, 2022
β-cyclodextrin has a unique annular hollow ultrastructure that allows encapsulation of various poorly water-soluble drugs in the resulting cavity, thereby increasing drug stability.
Kunqian Mu   +7 more
doaj   +1 more source

Impact of Naturally Contaminated Substrates on Alphitobius diaperinus and Hermetia illucens: Uptake and Excretion of Mycotoxins

open access: yesToxins, 2019
Insects are considered a suitable alternative feed for livestock production and their use is nowadays regulated in the European Union by the European Commission Regulation No. 893/2017.
Giulia Leni   +6 more
doaj   +1 more source

Preclinical Drug Pharmacokinetic, Tissue Distribution and Excretion Profiles of the Novel Limonin Derivate HY-071085 as an Anti-Inflammatory and Analgesic Candidate in Rats and Beagle Dogs

open access: yesPharmaceuticals, 2022
Limonin is one of the research hotspots in natural drug development. However, its low solubility in water leads to poor oral bioavailability, discouraging the further study of its potential as a candidate compound.
Liping Dong   +5 more
doaj   +1 more source

From salt to hypertension, what is missed?

open access: yesThe Journal of Clinical Hypertension, 2021
Excess salt intake is viewed as a major contributor to hypertension and cardiovascular disease, and dietary salt restriction is broadly recommended by public health guidelines.
Zhiyi Ma   +3 more
doaj   +1 more source

Pharmacokinetics and Biological Activity of Cucurbitacins

open access: yesPharmaceuticals, 2022
Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and anticancer biological actions.
Eugenia Elisa Delgado-Tiburcio   +6 more
doaj   +1 more source

Extracellular Production of Glutathione by Recombinant Escherichia coli K-12

open access: yesMicrobiology Research, 2023
The goal of this study was to produce a sufficient amount of glutathione in the fermentation medium without the addition of cysteine. This would simplify and reduce the cost of its purification.
Hideyuki Suzuki   +2 more
doaj   +1 more source

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

open access: yesPharmacology Research & Perspectives, 2020
The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA ...
Ali R. Banijamali   +10 more
doaj   +1 more source

Endocytosis, Distribution, and Exocytosis of Polystyrene Nanoparticles in Human Lung Cells

open access: yesNanomaterials, 2022
Nanoplastics, one component of plastic pollution, can enter human bodies via inhalation and thus threaten human health. However, the knowledge about the uptake and exocytosis of nanoplastics in cells of human lung organs is still very limited. Herein, we
Yuan-Yuan Liu   +9 more
doaj   +1 more source

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