Results 11 to 20 of about 582,301 (339)

Investigating Stoichiometric Controls of Nutrient Recycling in Rivers Using the Threespine Stickleback (Gasterosteus aculeatus) [PDF]

Ecology and Evolution
In freshwater ecosystems, fish play a critical role in regulating the standing stock and turnover rates of biologically important elements such as nitrogen (N) and phosphorus (P).
Sarah R. Rozanski, Emily M. May, Rana W. El‐Sabaawi   +2 more
doaj   +2 more sources

Intracellular Localization during Blood–Brain Barrier Crossing Influences Extracellular Release and Uptake of Fluorescent Nanoprobes

Nanomaterials, 2023
To improve the efficacy of nanoparticles (NPs) and boost their theragnostic potential for brain diseases, it is key to understand the mechanisms controlling blood–brain barrier (BBB) crossing.
Ornella Muscetti, Naym Blal, Valentina Mollo, Paolo Antonio Netti, Daniela Guarnieri   +4 more
doaj   +1 more source

Experimental Infection of Captive Red Foxes (Vulpes vulpes) with Mycobacterium bovis

Microorganisms, 2022
In Europe, animal tuberculosis (TB) due to Mycobacterium bovis involves multi-host communities that include cattle and wildlife species, such as wild boar (Sus scrofa), badgers (Meles meles) and red deer (Cervus elaphus).
Céline Richomme, Sandrine Lesellier, Francisco Javier Salguero, Jacques Laurent Barrat, Jean-Marc Boucher, Jennifer Danaidae Reyes-Reyes, Sylvie Hénault, Krystel De Cruz, Jennifer Tambosco, Lorraine Michelet, Justine Boutet, Rubyat Elahi, Konstantin P. Lyashchenko, Conor O’Halloran, Ana Balseiro, Maria Laura Boschiroli   +15 more
doaj   +1 more source

24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk.

New England Journal of Medicine, 2021
BACKGROUND The relation between sodium intake and cardiovascular disease remains controversial, owing in part to inaccurate assessment of sodium intake.
Yuan Ma, F. He, Qi Sun, Changzheng Yuan, L. Kieneker, G. Curhan, G. MacGregor, S. Bakker, N. Campbell, Molin Wang, E. Rimm, J. Manson, W. Willett, A. Hofman, R. Gansevoort, N. Cook, F. Hu   +16 more
semanticscholar   +1 more source

PHARMACOKINETIC PROPERTIES OF A NEW KAPPA-OPIOID ANALGESIC RU-1205 COMPOUND AT A SINGLE PERORAL ADMINISTRATION

Фармация и фармакология (Пятигорск), 2021
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between its ...
A. A. Spasov, L. A. Smirnova, O. Yu. Grechko, N. V. Eliseeva, Yu. V. Lifanova, A. I. Rashchenko, O. N. Zhukovskaya, A. S. Morkovnik, V. A. Anisimova   +8 more
doaj   +1 more source

Pharmacokinetics and Excretion Study of Lycium barbarum Polysaccharides in Rats by FITC-Fluorescence Labeling

Foods, 2021
A high-performance gel permeation chromatography fluorescence detection (HPGPC-FD) method combined with fluorescein isothiocyanate (FITC) labeling was established for the microanalysis of L. barbarum polysaccharides (LBP).
Hui Xia, Chao Yang, Beijia Zhou, Huali Tang, Ligang Yang, Wang Liao, Guiju Sun   +6 more
doaj   +1 more source

Pharmacokinetics, absorption, distribution, metabolism and excretion of the MEK inhibitor zapnometinib in rats

Frontiers in Pharmacology, 2022
Zapnometinib is a MEK inhibitor currently under clinical development for the treatment of COVID-19 and influenza. Zapnometinib has both antiviral and immunomodulatory effects. Information concerning the absorption, distribution, metabolism, and excretion
Yvonne Füll, Yvonne Füll, Christian Wallasch, Ashley Hilton, Oliver Planz, Oliver Planz   +5 more
doaj   +1 more source

Pharmacokinetics, bioavailability, and excretion of ponazuril in piglets

Frontiers in Veterinary Science, 2022
Ponazuril is a triazine anticoccidial drug which is the main metabolite of toltrazuril in animals, it has excellent activity against many protozoa, including Cystoisospora suis, and has broad application prospects in the control of swine coccidiosis.
Wenxiang Wang, Yuqiao Ma, Yunxiao Zhang, Jingjing Nie, Daxing Hu, Weicong Yang, Yue Shen, Xinglong Cui, Huanzhong Ding, Li Li, Xianhui Huang   +10 more
doaj   +1 more source

Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1

Frontiers in Pharmacology, 2021
The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane.
Giuliano Ciarimboli
doaj   +1 more source

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

Nature Communications, 2020
The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find
K. Hoque, E. Dixon, Raychel M. Lewis, Jordyn Allan, G. Gamble, A. Phipps-Green, Victoria L. Halperin Kuhns, A. Horne, L. Stamp, T. Merriman, N. Dalbeth, O. Woodward   +11 more
semanticscholar   +1 more source