Results 31 to 40 of about 582,301 (339)

Pre-Clinical Pharmacokinetic Characterization, Tissue Distribution, and Excretion Studies of Novel Edaravone Oral Prodrug, TEJ-1704

Pharmaceutics, 2021
Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a free radical scavenger approved for the treatment of amyotrophic lateral sclerosis, a fatal neuromuscular disease. Edaravone is administered as an intravenous infusion over 60 min for several treatment
Dong Wook Kang, Ju Hee Kim, Kyung Min Kim, Seok-jin Cho, Hee-Woon Jang, Ji Won Chang, Seung Myung Dong, Jee Woong Lim, Jae-Sun Kim, Hea-Young Cho   +9 more
doaj   +1 more source

Association of Urinary Oxalate Excretion With the Risk of Chronic Kidney Disease Progression

JAMA Internal Medicine, 2019
Importance Oxalate is a potentially toxic terminal metabolite that is eliminated primarily by the kidneys. Oxalate nephropathy is a well-known complication of rare genetic disorders and enteric hyperoxaluria, but oxalate has not been investigated as a ...
S. Waikar, Anand Srivastava, R. Palsson, T. Shafi, Chi-yuan Hsu, K. Sharma, J. Lash, J. Chen, Jiang He, J. Lieske, D. Xie, Xiaoming Zhang, H. Feldman, G. Curhan   +13 more
semanticscholar   +1 more source

Preclinical Bioavailability, Tissue Distribution, and Protein Binding Studies of Erinacine A, a Bioactive Compound from Hericium erinaceus Mycelia Using Validated LC-MS/MS Method

Molecules, 2021
Erinacine A, derived from the mycelia of Hericium erinaceus, has attracted much attention due to its neuroprotective properties. However, very few studies have been conducted on the bioavailability, tissue distribution, and protein binding of erinacine A.
Pei-Ching Tsai, Yi-Kai Wu, Jun-Hao Hu, I-Chen Li, Ting-Wei Lin, Chin-Chu Chen, Chia-Feng Kuo   +6 more
doaj   +1 more source

Absorption, metabolism, and excretion of [14C]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers

Pharmacology Research & Perspectives, 2023
Dersimelagon (formerly MT‐7117) is a novel, orally administered nonpeptide small molecule selective agonist for melanocortin 1 receptor currently being investigated for the treatment of erythropoietic protoporphyria, X‐linked protoporphyria, and diffuse ...
Minoru Tsuda, Kei Ogawa, Tadashi Endou, Takahiro Goto, Yuko Ogasawara, Akihito Ogasawara   +5 more
doaj   +1 more source

Pharmacokinetics of Antibacterial Agents in the Elderly: The Body of Evidence

Biomedicines, 2023
Infections are important factors contributing to the morbidity and mortality among elderly patients. High rates of consumption of antimicrobial agents by the elderly may result in increased risk of toxic reactions, deteriorating functions of various ...
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov, Elena A. Baybulatova   +4 more
doaj   +1 more source

Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract From Selaginella doederleinii

Frontiers in Pharmacology, 2022
Graphical ...
Bing Chen, Bing Chen, Dafen Xu, Dafen Xu, Zhijun Li, Yafei Jing, Luping Lin, Shaoguang Li, Liying Huang, Xiuwang Huang, Ailin Liu, Xinhua Lin, Xinhua Lin, Hong Yao, Hong Yao   +14 more
doaj   +1 more source

In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS2 (M = Mo, W, Ti) Nanosheets

Advancement of science, 2016
With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in
Jiali Hao, Guosheng Song, Teng Liu, Xuan Yi, Kai Yang, Liang Cheng, Zhuang Liu   +6 more
semanticscholar   +1 more source

Investigation of 131I kinetics in the rats organism after a single intake [PDF]

Ядерна фізика та енергетика, 2012
Kinetics of 131I in the organism of the laboratory rats is investigated after a single intake of various activities of isotopes. The isotope content is measured in different organs and tissues. Half-life of 131I has been determined.
I. P. Drozd, A. I. Lypska, L. K. Bezdrobna, V. A. Shytiuk, O. A. Sova   +4 more
doaj  

Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats

Drug Design, Development and Therapy, 2021
Kai Pan,1,2 Xiaolei Shi,2 Kai Liu,3 Ju Wang,2 Yijun Chen1 1State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, Nanjing, Jiangsu Province, 211198, People’s Republic of China; 2Jiangsu Hengrui ...
Pan K, Shi X, Liu K, Wang J, Chen Y
doaj  

Tolerance and Excretion of the Mycotoxins Aflatoxin B1, Zearalenone, Deoxynivalenol, and Ochratoxin A by Alphitobius diaperinus and Hermetia illucens from Contaminated Substrates

Toxins, 2018
This study aimed to investigate the potential accumulation of mycotoxins in the lesser mealworm (Alphitobius diaperinus, LMW) and black soldier fly (Hermetia illucens, BSF) larvae.
Louise Camenzuli, Ruud Van Dam, Theo de Rijk, Rob Andriessen, Jeroen Van Schelt, H. J. (Ine) Van der Fels-Klerx   +5 more
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