Results 31 to 40 of about 622,707 (285)

Preclinical Bioavailability, Tissue Distribution, and Protein Binding Studies of Erinacine A, a Bioactive Compound from Hericium erinaceus Mycelia Using Validated LC-MS/MS Method

Molecules, 2021
Erinacine A, derived from the mycelia of Hericium erinaceus, has attracted much attention due to its neuroprotective properties. However, very few studies have been conducted on the bioavailability, tissue distribution, and protein binding of erinacine A.
Pei-Ching Tsai, Yi-Kai Wu, Jun-Hao Hu, I-Chen Li, Ting-Wei Lin, Chin-Chu Chen, Chia-Feng Kuo   +6 more
doaj   +1 more source

Pharmacokinetics of Antibacterial Agents in the Elderly: The Body of Evidence

Biomedicines, 2023
Infections are important factors contributing to the morbidity and mortality among elderly patients. High rates of consumption of antimicrobial agents by the elderly may result in increased risk of toxic reactions, deteriorating functions of various ...
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov, Elena A. Baybulatova   +4 more
doaj   +1 more source

Time course of changes in 6-sulfatoxymelatonin excretion in patients with breast cancer after various neoadjuvant chemotherapy options

Опухоли женской репродуктивной системы, 2014
The level of the metabolite 6-sulfatoxymelatonin (6-SOM) was studied on automedia before and after neoadjuvant systemic polyche- motherapy and neoadjuvant chemotherapy.
Yu. S. Sidorenko, O. I. Kit, A. E. Lisutin, O. M. Semiletkin   +3 more
doaj   +1 more source

Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract From Selaginella doederleinii

Frontiers in Pharmacology, 2022
Graphical ...
Bing Chen, Bing Chen, Dafen Xu, Dafen Xu, Zhijun Li, Yafei Jing, Luping Lin, Shaoguang Li, Liying Huang, Xiuwang Huang, Ailin Liu, Xinhua Lin, Xinhua Lin, Hong Yao, Hong Yao   +14 more
doaj   +1 more source

A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. [PDF]

, 2019
The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy.
Baker, Dewleen G, Biswas, Nilima, González-Sarmiento, Rogelio, Hightower, C Makena, Ichinose, Hiroshi, Kurosaki, Hiroki, León-Jiménez, David, Lipkowitz, Michael S, Mahata, Manjula, Miramontes-Gonzalez, Jose Pablo, Nievergelt, Caroline M, O'Connor, Daniel T, Schork, Andrew J, Vaingankar, Sucheta, Zhang, Kuixing, Ziegler, Michael G   +15 more
core   +2 more sources

Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis [PDF]

, 2018
We sought to decipher the mechanisms underlying the kidney's response to changes in K+ load and intake, under physiological and pathophysiological conditions.
Edwards, Aurelie, Layton, Anita T., Vallon, Volker   +2 more
core   +1 more source

Network pharmacology and molecular docking investigation of Curcuma xanthorrhiza Roxb. rhizome with the mechanisms underlying as the potential drug of eczema treatment

Journal of Advanced Pharmaceutical Technology & Research
A chronic inflammatory dermatosis, eczema, affects more than 12% of the pediatric population and 7.2% of adults. Clinically, it presents with erythematous, scaly, and intensely pruritic lesions.
Yusuf Alif Pratama, Honey Dzikri Marhaeny, Sulistyanengci Winarto, Igansius Agyo Palmado, Muhammad Hermawan Widyananda, Mahardian Rahmadi, Muhammad Taher, Ahmed Abdallah Hasan, Burkhard Kleuser, Junaidi Khotib   +9 more
doaj   +1 more source

Biomonitoring of deoxynivalenol and deoxynivalenol-3-glucoside in human volunteers : renal excretion profiles [PDF]

, 2019
Biomarkers for the determination of the dietary exposure to deoxynivalenol (DON) have been proposed in the past but so far no quantification of their use in humans has been carried out. Following a human intervention study with two mycotoxins, namely DON
De Boevre, Marthe, De Saeger, Sarah, Hoogenveen, Rudolf, Mengelers, Marcel, Vidal Corominas, Arnau, Zeilmaker, Marco   +5 more
core   +1 more source

Distribution and Excretion of Arsenic Metabolites after Oral Administration of Seafood-Related Organoarsenicals in Rats

Metals, 2016
Less information is available on the metabolism of organic arsenicals compared to inorganic arsenic in mammals. In the present study, we investigated tissue distribution, metabolism and excretion in rats of organoarsenicals, dimethylarsinic acid (DMAV ...
Yayoi Kobayashi, Seishiro Hirano
doaj   +1 more source

Investigating Stoichiometric Controls of Nutrient Recycling in Rivers Using the Threespine Stickleback (Gasterosteus aculeatus)

Ecology and Evolution
In freshwater ecosystems, fish play a critical role in regulating the standing stock and turnover rates of biologically important elements such as nitrogen (N) and phosphorus (P).
Sarah R. Rozanski, Emily M. May, Rana W. El‐Sabaawi   +2 more
doaj   +1 more source