Results 81 to 90 of about 622,707 (285)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The distribution and excretion of 1-Methylnaphthalene in rats exposed to 1-Methylnaphthalene by inhalation

International Journal of Occupational Medicine and Environmental Health, 2018
Objectives 1-Methylnaphthalene (1-MN) is a constituent of polycyclic aromatic hydrocarbons, the chemicals that have become ubiquitous in the environment as result of natural and industrial process.
Radosław Świercz, Wojciech Wąsowicz
doaj   +1 more source

Serum and urinary concentrations of arsenic, beryllium, cadmium and lead after an aerobic training period of six months in aerobic athletes and sedentary people

Journal of the International Society of Sports Nutrition, 2020
Aim The aim of the present study was to evaluate the possible effect of a period of 6 months of aerobic physical training on serum and urinary concentrations of arsenic (As), beryllium (Be), cadmium (Cd) and lead (Pb), potentially toxic minerals. Methods
Diego Muñoz, Francisco J. Grijota, Ignacio Bartolomé, Jesús Siquier-Coll, Víctor Toro-Román, Marcos Maynar   +5 more
doaj   +1 more source

Uranium exposure of the Swiss population based on 24-hour urinary excretion

Swiss Medical Weekly, 2020
AIM OF THE STUDY Important regional differences in uranium exposure exist because of varying uranium concentrations in soil, water and food. Comprehensive data on the exposure of the general population to uranium is, however, scarce. Based on
Judith Jenny-Burri, Annabelle Blanc, Rafael Aubert, Max Haldimann, Ursina Zürcher, Michel Burnier, Fred Paccaud, Murielle Bochud, Vincent Dudler   +8 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Microplastic size matters for absorption and excretion by Artemia salina and Acipenser ruthenus larvae in models of water pollution and food chain transfer

Acta Biologica Sibirica
Microplastics pervade the hydrosphere and inevitably come into contact with aquatic organisms. The study reports quantitative data on absorption and excretion of polystyrene microspheres 2 and 10 µm in diameter by zooplankton and fish larvae on the ...
Yulia A. Frank, Elena A. Interesova, Svetlana A. Filinova, Yuri A. Noskov, Danil S. Vorobiev   +4 more
doaj   +1 more source

The Stoichiometry of Nutrient Release by Terrestrial Herbivores and Its Ecosystem Consequences

Frontiers in Earth Science, 2017
It is widely recognized that the release of nutrients by herbivores via their waste products strongly impacts nutrient availability for autotrophs. The ratios of nitrogen (N) and phosphorus (P) recycled through herbivore release (i.e., waste N:P) are ...
Judith Sitters, Judith Sitters, Judith Sitters, Elisabeth S. Bakker, Michiel P. Veldhuis, G. F. Veen, Harry Olde Venterink, Michael J. Vanni   +7 more
doaj   +1 more source

Algal culture studies related to a Closed Ecological Life Support System (CELSS) [PDF]

Studies with algal cultures which relate to closed ecological life support systems (CELSS) are discussed. A description of a constant cell density apparatus for continuous culture of algae is included.
Fernandez, E., Ollinger, O., Radmer, R. O., Venables, A.   +3 more
core   +1 more source

Raised cortisol excretion rate in urine and contamination by topical steroids [PDF]

, 2001
No abstract ...
Davies, D.L., Evans, J., Kelly, C., Ogilvie, A., Shapiro, D., Wallace, A.M.   +5 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source