Results 41 to 50 of about 1,819,207 (290)

Executive Power: Rethinking the Modalities of Control [PDF]

open access: yes, 2018
The Honorable Sundaresh Menon, Chief Justice of the Supreme Court of Singapore, delivered the 2018-2019 Bernstein Lecture in Comparative Law titled Executive Power: Rethinking the Modalities of Control.
Menon, Sundaresh
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Association between childhood obesity and ERP measures of executive control

open access: yesJournal of Physical Fitness and Sports Medicine, 2015
The worldwide pandemic of childhood obesity is now recognized as a serious public health concern. Several recent studies have indicated that childhood obesity is inversely associated with academic achievement, suggesting that maintaining a healthy weight
Keita Kamijo
doaj   +1 more source

The evolutionary origins of volition [PDF]

open access: yes, 2006
It appears to be a straightforward implication of distributed cognition principles that there is no integrated executive control system (e.g. Brooks 1991, Clark 1997). If distributed cognition is taken as a credible paradigm for cognitive science this in
Christensen, Dr Wayne
core  

The role of executive control in resolving grammatical number conflict in sentence comprehension [PDF]

open access: yes, 2017
In sentences with a complex subject noun phrase, like “The key to the cabinets is lost”, the grammatical number of the head noun (key) may be the same or different from the modifier noun phrase (cabinets).
Desmet, Timothy   +3 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Poor coherence in older people's speech is explained by impaired semantic and executive processes

open access: yeseLife, 2018
The ability to speak coherently is essential for effective communication but declines with age: older people more frequently produce tangential, off-topic speech. The cognitive factors underpinning this decline are poorly understood.
Paul Hoffman   +2 more
doaj   +1 more source

A Meta-Analysis of fMRI Studies of Youth Cannabis Use: Alterations in Executive Control, Social Cognition/Emotion Processing, and Reward Processing in Cannabis Using Youth

open access: yesBrain Sciences, 2022
Background: Adolescent cannabis use (CU) is associated with adverse health outcomes and may be increasing in response to changing cannabis laws. Recent imaging studies have identified differences in brain activity between adult CU and controls that are ...
Christopher J. Hammond   +8 more
doaj   +1 more source

The influence of working memory load on response inhibition in children with attention-deficit/hyperactivity disorder or reading disorder [PDF]

open access: yes, 2011
The aim of the present study was to examine the relationship between response inhibition and working memory in 8-12-year-old children with attention-deficit/hyperactivity disorder (ADHD; n = 19), reading disorder (RD; n = 17), ADHD + RD (n = 21), and ...
Roeyers, Herbert   +3 more
core   +2 more sources

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