Results 61 to 70 of about 11,677,620 (399)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Shifting gear in the study of the bilingual advantage : language switching examined as a possible moderator [PDF]

, 2019
The bilingual advantage is a heavily debated topic in research on bilingualism. The current study further investigated one specific aspect of bilingualism proposed to be a determining factor for the bilingual advantage, namely language switching ...
Struys, Esli, Van Herck, Shauni, Woumans, Evy   +2 more
core   +3 more sources

Executive Functions and Foreign Language Learning

Pediatric Reports, 2022
Executive functions (EFs) serve as an umbrella term to describe a set of higher-order cognitive abilities that include working memory, inhibitory control, cognitive flexibility, planning, reasoning, and problem-solving.
Alessandro Frolli, Francesco Cerciello, Clara Esposito, Sonia Ciotola, Gaia De Candia, Maria Carla Ricci, Maria Grazia Russo   +6 more
doaj   +1 more source

The relationships between rumination and core executive functions: A meta‐analysis

Depression and Anxiety, 2017
Rumination has been thought to relate to deficits in core executive functions (EFs), but the empirical findings for this idea are mixed. The aim of the present study is to synthesize existing literature to clarify these relations.
Yingkai Yang, Songfeng Cao, G. Shields, Zhaojun Teng, Yanling Liu   +4 more
semanticscholar   +1 more source

Executive functions and their disorders [PDF]

British Medical Bulletin, 2003
The term executive function defines complex cognitive processing requiring the co-ordination of several subprocesses to achieve a particular goal. Neuropsychological evidence suggests that executive processing is intimately connected with the intact function of the frontal cortices.
openaire   +3 more sources

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

The role of executive functions in the control of aggressive behavior [PDF]

, 2015
An extensive literature suggests a link between executive functions and aggressive behavior in humans, pointing mostly to an inverse relationship, i.e., increased tendencies toward aggression in individuals scoring low on executive function tests.
Kopyciok, Robert P. J., Krämer, Ulrike M., Münte, Thomas F., Richter, Sylvia, Rodríguez Fornells, Antoni   +4 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Conditioning U.S. Security Assistance on Human Rights Practices [PDF]

, 1982
In the United States, with its government of separated powers and functions, it is the executive branch, and in particular the Department of State, that bears responsibility for implementing legislation on foreign relations. The success of implementation
Cohen, Stephen B.
core   +1 more source

ERP evidence suggests executive dysfunction in ecstasy polydrug users [PDF]

, 2013
Background: Deficits in executive functions such as access to semantic/long-term memory have been shown in ecstasy users in previous research. Equally, there have been many reports of equivocal findings in this area.
A Gamma, A Miyake, A Pazos, AC Parrott, AG Verstraete, AJ Saykin, AP Burgess, B Kopp, C Casco, C Montgomery, C Montgomery, C Montgomery, C Montgomery, C Montgomery, C Whitney, C. A. Roberts, C. Montgomery, D Badre, D Davison, DE Hinkle, DM McDowell, DT Stuss, E Jefferies, EM Bekker, F. Tames, G Jager, G Kanayama, HC Fox, J Cole, J. E. Fisk, JA Horne, JE Fisk, JH Halpern, JR Folstein, M Terman, MA Wetherell, MJ Morgan, N Yeung, PN Murphy, RL Carhart-Harris, RM Ruff, RM Shiffrin, S Bhattachary, S Mejias, S Nieuwenhuis, S Rossi, S Sola de, S Suwazono, S. H. Fairclough, SJ Luck, SL Rosell, T Akerstedt, V Veen van, W Ritter   +53 more
core   +1 more source