Results 61 to 70 of about 41,740 (271)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Associations of exercise procrastination and exercise addiction with mental well-being

Frontiers in Psychology
Exercise procrastination and exercise addiction reflect maladaptive patterns that may be linked to mental well-being, yet their dose–response relationships and potential mechanisms remain unclear.
Wenbo Ma, Yanxia Zhao, Hengzhi Deng, Yike Li, Zhengyang Mei, Lunxin Chen, Chao Wang, Xing Zhang, Weihua Zheng, Hansen Li   +9 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Unveiling the obsession: Exercise addiction among female amateur runners in Delhi-NCR and the power of unwavering commitment

Journal of Pharmacy and Bioallied Sciences
Aim and Objective: This study was intended for a possible relationship that might exist between exercise addiction and unbending commitment among female amateur runners. Exercise addiction (EA) can be characterized as an obsession with physical activity;
Indu Bala, Anita Manglani
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The relationship between exercise addiction, eating disorders, and insecure attachment styles among recreational exercisers

Journal of Eating Disorders, 2023
Background Exercise addiction (EA) and eating disorders (ED) frequently co-occur in both professional and amateur athletes, with up to 48% of individuals with EA also exhibiting symptoms of ED. Furthermore, pathological attachment styles have been linked
Dalit Lev Arey, Adi Sagi, Asaf Blatt
doaj   +1 more source

The Thin Ideal and Attitudes towards Appearance as Correlates of Exercise Addiction among Sporty People during the COVID-19 Pandemic

Behavioral Sciences, 2022
The stress and anxiety caused by the coronavirus pandemic (COVID-19) have exacerbated body image concerns. A society that perpetuates the attempt for a perfect and thin appearance represents a fertile ground for the development of exercise addiction (EA).
Rubinia Celeste Bonfanti, Gianluca Lo Coco, Laura Salerno, Maria Di Blasi   +3 more
doaj   +1 more source

Psychometric evaluation of the Italian Revised Exercise Addiction Inventory (EAI-R) among Italian speaking exercisers: Confirmatory factor analysis

, 2023
Background: The Exercise Addiction Inventory (EAI) is a valid and reliable instrument and has been used in numerous contexts and research studies. The EAI was recently revised (EAI-R), but the psychometric properties of the EAI-R have yet to be examined in an Italian context.
Paolo, Soraci, Attila, Szabo, Nicoletta, Vegni, Claudia, Prestano, Eleonora, Guaitoli, Carla, Di Bernardo, Luca, Orati, Roberta, Tiozzo Brasiola, Elisa, Chini, Claudia, Iraso, Laura, Abbatuccolo, Mark, D. Griffiths   +11 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Profiling and assessing the risks of image- and performance-enhancing drugs use during the COVID-19 lockdown

Frontiers in Public Health
BackgroundImage and Performance-Enhancing Drugs (IPEDs) can enhance mental and physical capabilities and impact one’s overall health. Initially confined in sport environments, IPEDs use has become increasingly widespread in a high-performing society. The
Ilaria De Luca, Francesco Di Carlo, Julius Burkauskas, Artemisa R. Dores, Artemisa R. Dores, Irene P. Carvalho, M. Ángeles Gómez-Martínez, Attila Szabo, Attila Szabo, Hironobu Fujiwara, Hironobu Fujiwara, Hironobu Fujiwara, Cristina Monteiro Barbosa, Marco Di Nicola, Marianna Mazza, Gabriele Sani, Debora Luciani, Mauro Pettorruso, Massimo di Giannantonio, Ilaria Cataldo, Gianluca Esposito, Giovanni Martinotti, Giovanni Martinotti, Thomas Zandonai, Olivier Rabin, Olivier Rabin, Ornella Corazza, Ornella Corazza   +27 more
doaj   +1 more source