Results 71 to 80 of about 1,671,153 (255)

Profiling and assessing the risks of image- and performance-enhancing drugs use during the COVID-19 lockdown

Frontiers in Public Health
BackgroundImage and Performance-Enhancing Drugs (IPEDs) can enhance mental and physical capabilities and impact one’s overall health. Initially confined in sport environments, IPEDs use has become increasingly widespread in a high-performing society. The
Ilaria De Luca, Francesco Di Carlo, Julius Burkauskas, Artemisa R. Dores, Artemisa R. Dores, Irene P. Carvalho, M. Ángeles Gómez-Martínez, Attila Szabo, Attila Szabo, Hironobu Fujiwara, Hironobu Fujiwara, Hironobu Fujiwara, Cristina Monteiro Barbosa, Marco Di Nicola, Marianna Mazza, Gabriele Sani, Debora Luciani, Mauro Pettorruso, Massimo di Giannantonio, Ilaria Cataldo, Gianluca Esposito, Giovanni Martinotti, Giovanni Martinotti, Thomas Zandonai, Olivier Rabin, Olivier Rabin, Ornella Corazza, Ornella Corazza   +27 more
doaj   +1 more source

Passion and exercise addiction [PDF]

, 2018
New evidence suggests that passion is linked to exercise addiction. The objective of this work was to determine the strength of the relationship between exercise addiction, obsessive passion, and harmonious passion in team versus individual sports ...
Vega, Ricardo de la, Szabó, Attila, Ruíz-Barquín, Roberto, Soós, István, de la Vega, Ricardo, Vega Marcos, Ricardo de la, Ruiz Barquín, Roberto, Kovácsik, Rita   +7 more
core   +1 more source

Exercise Addiction Stability and Health Effects. A 6-Month Follow-up Postcompetition Study in Amateur Endurance Cyclists

, 2022
Objective: To study the longitudinal stability of exercise addiction and its health effects in apparently healthy amateur endurance cyclists from pre- to 6-month post-competition.
Oviedo-Caro, Miguel Ángel, Munguía Izquierdo, Diego, Mayolas-Pi, Carmen, Guillén-Correas, Roberto, Legaz-Arrese, Alejandro, París-García, Federico, Bueno-Antequera, Javier   +6 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Risks of exercise addiction and eating disorders among women attending fitness classes

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
This article discusses the risks associated with exercise addiction (sport addiction) and eating disorders among women participating in fitness classes. The sample consisted of 190 women assigned to an experimental group (N=114) and healthy control group
O. V. Felsendorff, A. Y. Egorov
doaj  

The relationship between physical exercise and academic burnout in adolescents: the chain-mediated role of internet addiction and self-control

Frontiers in Psychology
BackgroundAcademic burnout represents a pressing issue among adolescents in China and has garnered increasing attention from scholars in the sport science domain.
Jianbin Du, Jiahui Dong, Yan Shi, Enmeng Jiang, Lin Mo, Bingzhi Wan, Bingzhi Wan   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Use of Image and Performance Enhancing Drugs During the Covid-19 Lockdown: a Cross-Cultural Study on Potential Users and Associated Risks

Emerging Trends in Drugs, Addictions, and Health
Introduction: Image and performance-enhancing drugs (IPEDs), or lifestyle drugs, are a wide range of products presented as having the potential to improve mental and physical function and health.
I. De Luca, F. Di Carlo, J. Burkauskas, A.R. Dores, M.A. Gómez-Martínez, A. Szabo, H. Fujiwara, C. Monteiro, M. Di Nicola, M. Mazza, G. Sani, D. Luciani, M. Pettorruso, M. di Giannantonio, I. Cataldo, G. Esposito, G. Martinotti, O. Corazza   +17 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source