Results 11 to 20 of about 271,644 (312)

Exhaustion, non-exhaustion and implied licence [PDF]

IIC - International Review of Intellectual Property and Competition Law, 2018
This article explores how exhaustion and non-exhaustion of certain rights can be more coherently explained using the common law doctrine of implied licence.
Mysoor, Poorna
core   +2 more sources

Heat exhaustion

, 2018
Heat exhaustion is part of a spectrum of heat-related illnesses that can affect all individuals, although children, older adults, and those with chronic disease are particularly vulnerable due to their impaired ability to dissipate heat.
Kenny G.P., Wilson T.E., Flouris A.D., Fujii N.
core   +3 more sources

Intervening for exhaustion [PDF]

Journal of Psychosomatic Research, 2006
First paragraph: The search for psychosocial factors that contribute to the aetiology and course of coronary heart disease (CHD) has been an energetic, although not always fruitful, pursuit for more than half a century. Around 20 years ago, Appels [1] identified a prodromal constellation of symptoms, including physical exhaustion and feelings of ...
Carroll, Douglas, Macleod, John, Phillips, Anna C   +2 more
openaire   +4 more sources

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia

Frontiers in Immunology, 2023
IntroductionDespite accumulated evidence in T-cell exhaustion in acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade in AML failed to achieve satisfying efficacy ...
Yueting Huang, Yueting Huang, Huijian Zheng, Huijian Zheng, Yuwen Zhu, Yuwen Zhu, Yan Hong, Yan Hong, Jie Zha, Jie Zha, Zhijuan Lin, Zhijuan Lin, Zhifeng Li, Zhifeng Li, Caiyan Wang, Caiyan Wang, Zhihong Fang, Zhihong Fang, Xingxing Yu, Xingxing Yu, Long Liu, Long Liu, Bing Xu, Bing Xu   +23 more
doaj   +1 more source

Analysis of single‐cell RNAseq identifies transitional states of T cells associated with hepatocellular carcinoma

Clinical and Translational Medicine, 2020
Background Exhausted T cells and regulatory T cells (Tregs) comprise diverse subsets of tumor immunosuppressive microenvironment that play key roles in tumor progress. Understanding subset diversity in T cells is a critical question for developing cancer
Yanying Yang, Fangming Liu, Weiren Liu, Mingyue Ma, Jie Gao, Yan Lu, Li‐Hao Huang, Xiaoying Li, Yinghong Shi, Xiangdong Wang, Duojiao Wu   +10 more
doaj   +1 more source

A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

eLife, 2022
CD4+ T cells are critical orchestrators of immune responses against a large variety of pathogens, including viruses. While multiple CD4+ T cell subtypes and their key transcriptional regulators have been identified, there is a lack of consistent ...
Massimo Andreatta, Ariel Tjitropranoto, Zachary Sherman, Michael C Kelly, Thomas Ciucci, Santiago J Carmona   +5 more
doaj   +1 more source

Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress

Frontiers in Psychiatry, 2020
ObjectiveAdolescent depression is a heterogeneous disorder, with a wide variety of symptoms and inconsistent treatment response, and is not completely understood.
Toon van der Gronde, Leontien Los, Arnoud Herremans, Ronald Oosting, Rafaela Zorzanelli, Toine Pieters   +5 more
doaj   +1 more source

HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

Frontiers in Immunology, 2022
Lymphoid tissues are an important HIV reservoir site that persists in the face of antiretroviral therapy and natural immunity. Targeting these reservoirs by harnessing the antiviral activity of local tissue-resident memory (TRM) CD8+ T-cells is of great ...
Rabiah Fardoos, Rabiah Fardoos, Sarah K. Nyquist, Sarah K. Nyquist, Osaretin E. Asowata, Samuel W. Kazer, Alveera Singh, Abigail Ngoepe, Jennifer Giandhari, Ntombifuthi Mthabela, Dirhona Ramjit, Samita Singh, Farina Karim, Søren Buus, Frank Anderson, J. Zachary Porterfield, J. Zachary Porterfield, J. Zachary Porterfield, J. Zachary Porterfield, Andile L. Sibiya, Rishan Bipath, Kumeshan Moodley, Warren Kuhn, Warren Kuhn, Bonnie Berger, Son Nguyen, Tulio de Oliveira, Thumbi Ndung’u, Thumbi Ndung’u, Thumbi Ndung’u, Philip Goulder, Philip Goulder, Philip Goulder, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alasdair Leslie, Alasdair Leslie, Henrik N. Kløverpris, Henrik N. Kløverpris, Henrik N. Kløverpris   +40 more
doaj   +1 more source

The Complex Interplay Between Emotion Regulation and Work Rumination on Exhaustion

Frontiers in Psychology, 2019
This study examined the interplay between emotion regulation strategies (reappraisal and suppression) and work-related rumination (affective work rumination and detachment from work) on exhaustion.
Martin Geisler, Sandra Buratti, Carl Martin Allwood   +2 more
doaj   +1 more source

B7-H7 Is Inducible on T Cells to Regulate Their Immune Response and Serves as a Marker for Exhaustion

Frontiers in Immunology, 2021
The discovery of immune checkpoints highlights the complexity of T cell signalling during an immune response. Upon activation, T cells express several molecules to regulate their function and to prevent overactivation.
Khang Luu, Khang Luu, Khang Luu, Khang Luu, Khang Luu, Herbert Schwarz, Herbert Schwarz, Herbert Schwarz, Herbert Schwarz, Andreas Lundqvist   +9 more
doaj   +1 more source