Results 191 to 200 of about 604,131 (324)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Propagation of monocyte exhaustion memory and underlying mechanisms. [PDF]

Cell Commun Signal
Wang J, Caldwell BA, Wu Y, Razani B, Li L.   +4 more
europepmc   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Toward a Better Understanding of Emotional Exhaustion Among First-Line Nurse Managers: The Role of Psychological Stress, Presenteeism, and Leader Loyalty. [PDF]

J Nurs Manag
Achmet V, Lauzier M.
europepmc   +1 more source

PREDICTION OF CREEP-FATIGUE LIVES FOR FBR AND BOILER MATERIALS BASED ON DUCTILITY EXHAUSTION CONCEPT

, 1997
Isamu Nonaka, Shoji TORIHATA, Shigemitsu Kihara   +2 more
openalex   +2 more sources

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Effects of Aerobic Exercise on Myocardial Injury in Sleep Deprived Mice. [PDF]

Nat Sci Sleep
Zhao J, Zhang D, Li X, Zhu A.
europepmc   +1 more source

Work-to-family conflict and firm performance of women entrepreneurs: Roles of work-related emotional exhaustion and competitive hostility

, 2021
Dirk De Clercq, Eugène Kaciak, Narongsak Thongpapanl   +2 more
openalex   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

CAR-T cell exhaustion in B cell lymphoma: Current status, mechanisms, and potential solutions. [PDF]

Mol Ther Oncol
Zhao R, Xia J, Zheng Y, Huang W, Yu L, Wang L.   +5 more
europepmc   +1 more source