Results 41 to 50 of about 604,131 (324)

Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion

Frontiers in Immunology
BackgroundAnti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia.
Shufeng Xie, Shufeng Xie, Jinlan Long, Ruiheng Wang, Ruiheng Wang, Rufang Xiang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu   +17 more
doaj   +1 more source

Comparison of Peak Oxygen Uptake and Test-Retest Reliability of Physiological Parameters between Closed-End and Incremental Upper-Body Poling Tests

Frontiers in Physiology, 2017
Objective: To compare peak oxygen uptake (VO2peak) and the test-retest reliability of physiological parameters between a 1-min and a 3-min closed-end and an incremental open-end upper-body poling test.Methods: On two separate test days, 24 healthy, upper-
Julia K. Baumgart, Knut Skovereng, Øyvind Sandbakk   +2 more
doaj   +1 more source

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes

Frontiers in Psychiatry, 2023
A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight ...
Johannes Hebebrand, Jochen Antel, Linda von Piechowski, Cordula Kiewert, Burkhard Stüve, Burkhard Stüve, Gertraud Gradl-Dietsch   +6 more
doaj   +1 more source

Exhaustion of Nucleation in a Closed System

, 2008
We determine the distribution of cluster sizes that emerges from an initial phase of homogeneous aggregation with conserved total particle density. The physical ingredients behind the predictions are essentially classical: Super-critical nuclei are ...
D. T. Wu, J. B. Zeldovich, John C. Neu, R. Becker, V. A. Shneidman, Yossi Farjoun   +5 more
core   +1 more source

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]

, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed, Burwitz, Benjamin J, Chew, Glen M, Clayton, Kiera L, Deeks, Steven G, Fujita, Tsuyoshi, Hammond, Katherine B, Hansen, Scott G, Hecht, Frederick M, Ishii, Naoto, Korman, Alan J, Liegler, Teri, Maurer, Mark, Mitchell, Brooks I, Ndhlovu, Lishomwa C, Ostrowski, Mario, Reed, Jason S, Sacha, Jonah B, Shikuma, Cecilia M, Webb, Gabriela M, Wu, Helen L   +20 more
core   +3 more sources

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Deleuze and Kieślowski: On the Cinema of Exhaustion

Film-Philosophy, 2017
This article revisits Krzysztof Kieślowski's films in light of Gilles Deleuze's writings on cinema. Its central argument is that, while Kieślowski's films register what Deleuze calls exhausted life, or la vie épuisée, they also offer an affirmative ...
Eddy Troy
doaj   +1 more source

Thiophene based monoazo disperse dyes for polyester fabric [PDF]

Journal of the Serbian Chemical Society, 2002
A series of monoazo disperse dyes have been prepared by coupling 2-amino 3-carbethoxy-4,5-dimethylthiophene with various N-arylmaleimides. The monoazo disperse dyes were characterised by IR spectral studies and elemental analysis. These dyes were applied
Maradiya Hari Raghav, Patel Vithal Soma
doaj   +1 more source

Prevention of CD8 T Cell Deletion during Chronic Viral Infection

Viruses, 2021
During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physically
David G. Brooks, Antoinette Tishon, Michael B. A. Oldstone, Dorian B. McGavern   +3 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source