Results 131 to 140 of about 6,731,721 (317)

Existence

Crítica (México D. F. En línea), 1984
En la sección I hago un análisis parcial de los conceptos normales de existencia, en parte para hacer una evaluación de la posición de Murray Kiteley sobre la existencia en “Is Existence a Predicate?”. Él correctamente argumenta que ‘existencia’ tiene dos usos importantes, uno de los cuales —el uso llamado “no excluyente” (‘existencia1’)— no es un ...
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A Singular nonlinear problems with natural growth in the gradient

Mathematical Modelling and Analysis
In this paper, we consider the equation  with boundary conditions where  is an open bounded subset of is a Leray-Lions operator defined on is a characteristic function, and is a Carathéodory function such thatsign Forand sufficiently small, we prove ...
Boussad Hamour
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

On a Class of Nonlinear Elliptic Equations with General Growth in the Gradient

Mathematics
In this paper, we prove an existence and uniqueness result for a class of Dirichlet boundary value problems whose model is −Δpu=β|∇u|q+c|u|p−2u+fin Ω,u=0on ∂Ω, where Ω is an open bounded subset of RN, N≥2 ...
M. Francesca Betta, Anna Mercaldo, Roberta Volpicelli   +2 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Global conservation of phylogenetic diversity captures more than just functional diversity

Nature Communications, 2019
Nisha R. Owen, Rikki Gumbs, Claudia L. Gray, Daniel P. Faith   +3 more
doaj   +1 more source

Existence and Stability for Fractional Differential Equations with a ψ–Hilfer Fractional Derivative in the Caputo Sense

Mathematics
This article aims to explore the existence and stability of solutions to differential equations involving a ψ-Hilfer fractional derivative in the Caputo sense, which, compared to classical ψ-Hilfer fractional derivatives (in the Riemann–Liouville sense),
Wenchang He, Yuhang Jin, Luyao Wang, Ning Cai, Jia Mu   +4 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Propagation of perturbations for a sixth-order thin film equation

Electronic Journal of Differential Equations, 2012
We consider an initial-boundary problem for a sixth-order thin film equation, which arises in the industrial application of the isolation oxidation of silicon.
Zhenbang Li, Changchun Liu
doaj