Results 131 to 140 of about 6,496,822 (268)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Monitoring and investigation to control the brain network disease under immunotherapy by using fractional operator. [PDF]

Sci Rep
Farman M, Talib A, Jamil K, Nisar KS, Sambas A, Bayram M, Hafez M.   +6 more
europepmc   +1 more source

XXXIX.—On doubts respecting the Existence of Bird-catching Spiders [PDF]

W Macleay
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Communicating astrobiology and the search for life elsewhere: Speculations and promises of a developing scientific field in newspapers, press releases and papers. [PDF]

PLoS One
Albergaria D, Russo P, Smeets I, Heenatigala T, Vetter D.   +4 more
europepmc   +1 more source

FURTHER EVIDENCE FOR THE EXISTENCE OF SPECIFIC DIETARY ESSENTIALS FOR THE GUINEA PIG

, 1943
Gilbert J. Mannering, Mary Cannon, H.V. Barki, C.A. Elvehjem, E.B. Hart   +4 more
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Reclaiming Justice as Lived Praxis: A Phenomenological Critique of Social and Relational Justice in Nursing Practice. [PDF]

Nurs Philos
Tembo AC.
europepmc   +1 more source

X.—On the existence of distinct larval and sexual forms in the gemmiparous Oligochætous worms [PDF]

E. Ray Lankester
openalex   +1 more source

THE SOLUBILITY OF SILVER CHLORIDE IN DILUTE CHLORIDE SOLUTIONS AND THE EXISTENCE OF COMPLEX ARGENTICHLORIDE IONS. II.¹ [PDF]

, 1921
George S. Forbes, Harriet Isabelle Cole
openalex   +1 more source