Results 131 to 140 of about 8,161,835 (383)

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Singularly Perturbed Fractional Schrödinger Equations with Critical Growth

Advanced Nonlinear Studies, 2018
We are concerned with the following singularly perturbed fractional Schrödinger equation:
He Yi
doaj   +1 more source

IX. On the discovery of a novel type flint implements below the base of the Red Crag of Suffolk, proving the existence skilled workers of flint in the Pliocene age [PDF]

, 1912
Ray Lankester
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Wybrane aspekty wielorakiego znaczenia bytu i intencjonalności w ujęciu Franza Brentana i Martina Heideggera [PDF]

Argument, 2013
The text aims to acquaint the Reader with Franz Brentano’s doctoral dissertation Von der mannigfachen Bedeutung des Seienden nach Aristoteles (1862), which opens the Aristotelica series and that is known to have inspired young Heidegger to become a ...
Sonia KAMIŃSKA
doaj  

Parabolic Biased Infinity Laplacian Equation Related to the Biased Tug-of-War

Advanced Nonlinear Studies, 2019
In this paper, we study the parabolic inhomogeneous β-biased infinity Laplacian equation arising from the β-biased tug-of ...
Liu Fang, Jiang Feida
doaj   +1 more source

On the Existence of Systems of Periodic Solutions for Several Nonlinear Circuits. [PDF]

, 1952
Sigeru Mizohata
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

On the Existence of Syphilis in America before the Discovery by Columbus [PDF]

, 1883
WILLIAM F. WHITNEY
openalex   +1 more source