Results 131 to 140 of about 8,396,811 (368)

Existence, uniqueness, localization and minimization property of positive solutions for non-local problems involving discontinuous Kirchhoff functions

Advances in Nonlinear Analysis
Let Ω⊂Rn\Omega \subset {{\bf{R}}}^{n} be a smooth bounded domain. In this article, we prove a result of which the following is a by-product: Let q∈]0,1[q\in ]0,1{[}, α∈L∞(Ω)\alpha \in {L}^{\infty }\left(\Omega ), with α>0\alpha \gt 0, and k∈Nk\in {\bf{N}}
Ricceri Biagio
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Existence of positive solutions for eigenvalue problem of nonlinear fractional differential equations [PDF]

, 2012
Xiaoling Han, Hongliang Gao
openalex   +1 more source

Necessary and Sufficient Condition for the Existence of Zero-Determinant Strategies in Repeated Games

, 2022
M. Ueda
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Existence result and error bounds for a new class of inverse mixed quasi-variational inequalities [PDF]

, 2016
Xi Li, Yun-zhi Zou
openalex   +1 more source

Space-dependent variable-order time-fractional wave equation: Existence and uniqueness of its weak solution

, 2022
Karel Van Bockstal, Ahmed S. Hendy, Mahmoud A. Zaky   +2 more
openalex   +2 more sources

On the existence and functionality of topologically associating domains

Nature Genetics, 2020
Jonathan A. Beagan, Jennifer E. Phillips-Cremins   +1 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source