Results 121 to 130 of about 637,407 (329)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optimal pair of fixed points: existence, uniqueness and approximation

Fixed Point Theory and Algorithms for Sciences and Engineering
In this paper, we introduce a novel class of mappings, referred to as noncyclic generalized θ-contractions. By employing the geometric concept of W U C $WUC$ property in metric spaces, we establish new existence and convergence theorems for the fixed ...
A. Safari-Hafshejani, M. Gabeleh
doaj   +1 more source

Existence and uniqueness for a Ginzburg-Landau system for superconductivity

Electronic Journal of Differential Equations, 2020
We prove the existence of a unique solution for a time-dependent Ginzburg-Landau model in superconductivity under the Coulomb gauge. Also we prove the uniform-in-$\epsilon$ well-posedness of the solution, where $\epsilon$ is the coefficient of the ...
Jishan Fan, Yong Zhou
doaj  

Existence and uniqueness of the solutions to impulsive nonlinear integro-differential equations with nonlocal boundary conditions

Proceedings of the Institute of Mathematics and Mechanics,National Academy of Sciences of Azerbaijan, 2019
In the paper a system of ordinary impulsive integro-differential equations with nonlocal conditions is studied. At first the boundary value problem is reduced to the equivalent integral equation.
Misir J. Mardanov-Yagub A. Sharifov-Farah M. Zeynalli
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Existence of solutions to fractional order ordinary and delay differential equations and applications

Electronic Journal of Differential Equations, 2011
In this article, we discuss the existence and uniqueness of solution to fractional order ordinary and delay differential equations. We apply our results on the single species model of Lotka Volterra type.
Syed Abbas
doaj  

Existence and Uniqueness of Second-Order Impulsive Delay Differential Systems

Axioms
In this paper, we study the existence and uniqueness of second-order impulsive delay differential systems. Firstly, we define cosine-type and sine-type delay matrix functions, which are used to derive the solutions of the impulsive delay differential ...
Yingxia Zhou, Mengmeng Li
doaj   +1 more source

Liapunov fundtions and global existence without uniqueness [PDF]

Proceedings of the American Mathematical Society, 1970
In a recent paper J. Kato and A. Strauss character- ized the global existence of solutions of ani ordinary differenitial equation in terms of Liapunov functions in which they assumed the right hand side of the differential equatioln is locally Lipschitz. In the present paper a characterization of global existence of an ordinary differential equation is
openaire   +2 more sources

The Existence and Uniqueness of Initial-Boundary Value Problems of the Fractional Caputo-Fabrizio Differential Equations

Universal Journal of Mathematics and Applications, 2019
In this paper, the existence and uniqueness problem of the initial and boundary value problems of the linear fractional Caputo-Fabrizio differential equation of order $\sigma \in (1,2]$ have been investigated.
Ş. Toprakseven
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source