Results 141 to 150 of about 637,407 (329)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Study on existence and stability analysis for implicit neutral fractional differential equations of ABC derivative

Partial Differential Equations in Applied Mathematics
In this paper, we study the existence, uniqueness, and stability analysis of non-linear implicit neutral fractional differential equations involving the Atangana–Baleanu derivative in the Caputo sense. The Banach contraction principle theorem is employed
V. Sowbakiya, R. Nirmalkumar, K. Loganathan, C. Selvamani   +3 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Lyapunov matrices: Existence and uniqueness issues

IFAC Proceedings Volumes, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Existence and uniqueness of solutions for nonlocal p-Laplacian problems

Electronic Journal of Differential Equations, 2016
We study the existence and uniqueness of positive solutions to a class of nonlocal boundary-value problems involving the p-Laplacian. Our main tools are a variant of the Schaefer's fixed point theorem, an inequality which suitably handles the p ...
Behrouz Emamizadeh, Amin Farjudian
doaj  

Existence and uniqueness for a mixed fractional differential system with slit-strips conditions

Boundary Value Problems
This paper studies the existence and uniqueness of solutions for a new kind of mixed fractional differential systems with slit-strips conditions, containing Caputo-type fractional derivatives.
Pengyan Yu, Guoxi Ni, Chengmin Hou
doaj   +1 more source

Existence of Solutions to Fractional Differential Equations with Mixed Caputo–Riemann Derivative

Fractal and Fractional
The study of fractional differential equations is gaining increasing significance due to their wide-ranging applications across various fields. Different methods, including fixed-point theory, variational approaches, and the lower and upper solutions ...
Mahir Almatarneh, Sonuc Zorlu, Nazim I. Mahmudov   +2 more
doaj   +1 more source