Results 81 to 90 of about 504,362 (312)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Semigroups on Frechet spaces and equations with infinite delays
, 2007 In this paper, we show existence and uniqueness of a solution to a functional differential equation with infinite delay. We choose an appropriate Frechet space so as to cover a large class of functions to be used as initial functions to obtain existence ...
Sengadir, T
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
AIMS MathematicsThe existence and uniqueness of solutions to nonlinear ordinary differential equations with fractal-fractional derivatives, with Dirac-delta, exponential decay, power law, and generalized Mittag-Leffler kernels, have been the focus of this work.
Abdon Atangana, Seda İğret Araz
doaj +1 more source
Advances in Difference Equations, 2018 This paper discusses the existence and uniqueness of positive solutions for a periodic boundary value problem of a fractional differential equation in an ordered Banach space E.
Yibo Kong, Pengyu Chen
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
On the groundstate of octonionic matrix models in a ball
Physics Letters B, 2015 In this work we examine the existence and uniqueness of the groundstate of a SU(N)×G2 octonionic matrix model on a bounded domain of RN. The existence and uniqueness argument of the groundstate wavefunction follows from the Lax–Milgram theorem ...
L. Boulton +2 more
doaj +1 more source
Anisotropic equations: Uniqueness and existence results
Differential and Integral Equations, 2008 We study uniqueness of weak solutions for elliptic equations of the following type \[ -\partial_{x_{i}}\left( a_{i}(x,u)\left\vert \partial_{x_{i}}u\right\vert ^{p_{i}-2}\partial_{x_{i}}u\right) +b(x,u) =f(x), \] in a bounded domain $\Omega\subset{\mathbb{R}}^{n}$ with Lipschitz continuous boundary $\Gamma=\partial\Omega$.
Antontsev, Stanislav, Chipot, Michel
openaire +3 more sources