Results 111 to 120 of about 251,066 (317)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Existence of solutions and convergence results for dynamic initial value problems using lower and upper solutions

open access: yesElectronic Journal of Differential Equations, 2009
In this article, we study the existence of solutions to first order non-linear initial value problems within the field of "dynamic equations on time scales". We employ the method of upper and lower solutions and Schauder's fixed point theorem.
Atiya H. Zaidi
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Existence and non-existence of solutions for a p(x)-biharmonic problem

open access: yesElectronic Journal of Differential Equations, 2015
In this article, we study the following problem with Navier boundary conditions $$\displaylines{ \Delta (|\Delta u|^{p(x)-2}\Delta u)+|u|^{p(x)-2}u =\lambda |u|^{q(x)-2}u +\mu|u|^{\gamma(x)-2}u\quad \text{in } \Omega,\cr u=\Delta u=0 \quad \text{on
Ghasem A. Afrouzi   +2 more
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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