Results 121 to 130 of about 251,066 (317)

Existence and global behavior of solutions to fractional p-Laplacian parabolic problems

open access: yesElectronic Journal of Differential Equations, 2018
First, we discuss the existence, the uniqueness and the regularity of the weak solution to the following parabolic equation involving the fractional p-Laplacian, $$\displaylines{ u_t+(-\Delta)_{p}^su +g(x,u)= f(x,u)\quad \text{in } Q_T:=\Omega\times (
Jacques Giacomoni, Sweta Tiwari
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Existence of solutions for iterative differential equations

open access: yesElectronic Journal of Differential Equations, 2014
The presence of self-mapping increases the difficulty in proving the existence of solutions for general iterative differential equation. In this article we provide conditions for the existence of solutions for the initial value problem, in which the ...
Pingping Zhang, Xiaobing Gong
doaj  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Existence of solutions for fractional Hamiltonian systems

open access: yesElectronic Journal of Differential Equations, 2013
In this work we prove the existence of solutions for the fractional differential equation $$ _{t}D_{\infty}^{\alpha}(_{-\infty}D_{t}^{\alpha}u(t)) + L(t)u(t) = \nabla W(t,u(t)),\quad u\in H^{\alpha}(\mathbb{R}, \mathbb{R}^{N}). $$ where $\alpha
Cesar Torres
doaj  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

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