Results 41 to 50 of about 4,720 (242)

A PEDAGOGY FOR PLAY: THEORETICAL CONSIDERATIONS AND OPERATIONAL GUIDELINES FOR AN EDUCATIONAL PERSPECTIVE 0–6

Cadernos Cedes, 2023
In Italy the 0-6 educational institutions have always been characterized as a split system; the 0-6 integrated system was born on a legislative level only recently (Law No. 107/2015; Dlgs. No. 65/2017).
Donatella Savio
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Reprezentări filosofice ale unității existenței: prin credință noetică și credință perceptivă

Studii de Istorie a Filosofiei Româneşti, 2022
In the following paper, I suggest an interpretation of Petrovici’s and Merleau-Ponty’s philosophy, both of them structured in accordance with the concept of unity of existence (the world), itself given in a close relation with the idea about an ...
Viorel Cernica
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Existential constructions

, 2013
Existential constructions are normally defined as sentences in which some entity is associated with some location giving rise to the so-called locative paradigm which also involves the locative and the possessive construction (cf. Freeze 2001). In spite of the apparent simplicity of this approach, the assumption of an allegedly universal locative ...
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Agreement, Case and Definiteness in Balkan Existential Constructions

Balcania et Slavia
This paper discusses agreement and definiteness effects in existential constructions in Balkan existentials constructions. I build on the restriction on definiteness properties of existential pivots known as definiteness effect: post-copular pivots in
Frasson, Alberto
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Presentative Constructions in English and Lithuanian

Kalbotyra, 2002
The article focuses on the type of existential sentence which is known in linguistic literature as a presentative construction. This type is distinguished on functional grounds: its communicative function is to introduce a new entity into a discourse. In
Violeta Kahėdaitė
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