Results 111 to 120 of about 314,408 (190)

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, Volume 3, Issue 3, September 2026.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

Serum vitamin A concentration in dogs with experimentally induced exocrine pancreatic insufficiency

, 2002
Serum concentration of Vitamin A was determined in dogs with experimentally induced exocrine pancreatic insufficiency following oral administration of vitamin A, or pancreatic enzyme and vitamin A.
Papasteriadis, A., Roubies, N., Adamama-Moraitou, K. K., Rallis, T. S., Prassinos, N. N.   +4 more
core   +1 more source

Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose‐Induced Insulin Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Suppression of BDNF‐TrkB signaling has shown a protective trend on hepatic oxidative stress by reducing sucrose‐induced lipid peroxidation. BDNF–TrkB signaling pathway plays a peripheral role in regulating mitochondrial enzyme capacity and redox balance in the liver.
Akın Bodur, Hüseyin Çınar Zihni, Katip Korkmaz, Solmaz Bodur, Ahmet Alver   +4 more
wiley   +1 more source

Primary exocrine pancreatic insufficiency in children (a clinical case of Shwachman-Diamond syndrome)

Zdorovʹe Rebenka
The purpose of the article is to increase the vigilance of clinicians in various fields of medicine to Shwachman-Diamond syndrome in children and to raise awareness of its clinical manifestations, diagnosis and treatment using the example of the case ...
V.S. Berezenko, Yu.I. Proshchenko, Kh.Z. Mykhayluk, M.B. Dyba, O.M. Tkalik, Yu.O. Savenko   +5 more
doaj   +1 more source

Management of Refractory and Difficult‐To‐Treat Inflammatory Bowel Disease: An Expert Opinion Review

JCC Plus, Volume 1, Issue 5, September 2026.
This expert opinion offers a practical framework for refractory and difficult‐to‐treat IBD: confirm inflammation objectively, distinguish pharmacologic from structural and functional disease, and then escalate. Across ten clinical questions, the evidence is often limited to case series, and the resulting statements are identified as expert opinion ...
Filiz Akyuz, Oguz Kagan Bakkaloglu, Nalan Gulsen Unal, Ismail Hakki Kalkan, Mehmet Arhan, Ibrahim Hatemi, Taylan Kav, Murat Toruner, Hale Akpinar, Ahmet Tezel, Aykut Ferhat Celik   +10 more
wiley   +1 more source

Plasma Proteomic Profiling Identifies Candidate Biomarkers for Pancreatic Ductal Adenocarcinoma

Journal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.
Using DIA‐based plasma proteomics followed by ELISA validation, we identified eight circulating proteins that were significantly elevated in patients with pancreatic ductal adenocarcinoma. These proteins reflect key tumor‐associated biological processes, including exocrine dysfunction and immune remodeling, and may serve as candidates for future multi ...
Lelang Xiang, Yi Jin, Ran Hu, Yuhang He, Yong Zhang, Ang Li   +5 more
wiley   +1 more source

Acute and Chronic Pancreatitis in Mitochondrial Disease: A Systematic Review

JIMD Reports, Volume 67, Issue 5, September 2026.
ABSTRACT Mitochondrial disease is a common inherited multisystem neurometabolic disorder. Pancreatic dysfunction is a recognised manifestation, most frequently presenting as mitochondrial diabetes. Although pancreatitis cases have been reported in association with mitochondrial disease, acute and chronic pancreatitis in this context remain poorly ...
Olivia Hahl, Mika H. Martikainen
wiley   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Role of Tertiary Lymphoid Structures in Autoimmune Diseases and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Schematic overview of tertiary lymphoid structures (TLSs): The development process, detection, and the immune function that depends on the environment in different disease contexts of TLS. TLSs originate from loose lymphoid aggregates that acquire ordered follicular architecture to become primary follicular‐like TLS, before maturing into ...
Ze Yan, Bin Wen, Ying Hu, Xiaocui Wang, Xuemei Duan, Haonan Li, Shumin Dong, Yufeng Fan, Caihong Wang, Shutong Yang, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

Isolated immune-related pancreatic exocrine insufficiency associated with pembrolizumab therapy

, 2018
We report a case of isolated immune-related pancreatic exocrine insufficiency in a patient treated with pembrolizumab for metastatic melanoma. This patient presented with explosive diarrhea and was treated with high dose corticosteroids for possible ...
Catriona M McNeil, Theresa Nielsen, David Parkin, Thiru Prasanna   +3 more
core   +1 more source