The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells [PDF]
, 1989 The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O.
Ahnert-Hilger, G. +4 more
core +1 more source
Exocytosis of the silicified cell wall of diatoms involves extensive membrane disintegration
Nature Communications, 2023 Exocytosis is a fundamental cellular process. Here, the authors report an unusual exocytosis mechanism in the silicified cell wall of diatoms, in which membrane patches are discarded.
Diede de Haan +8 more
doaj +1 more source
Journal of Cell Biology, 2015 Annexin A2 and the actin cytoskeleton are essential partners in providing lipid platforms for granule recruitment and fusion during exocytosis.
M. Gabel +7 more
semanticscholar +1 more source
Septin Dynamics Are Essential for Exocytosis*
Journal of Biological Chemistry, 2015 Background: Septins serve as scaffolds for membrane-associated protein complexes. Results: Knockdown of septin-2 or disruption of septin assembly/disassembly impairs interactions between exocytic proteins and inhibits late steps of exocytosis. Conclusion:
E. Tokhtaeva +10 more
semanticscholar +1 more source
Regulation of plasma membrane expansion during axon formation [PDF]
, 2018 Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano +2 more
core +1 more source
Journal of Cell Biology, 1979 We describe the design and operation of a machine that freezes biological tissues by contact with a cold metal block, which incorporates a timing circuit that stimulates frog neuromuscular junctions in the last few milliseconds before thay are frozen. We
J. Heuser +5 more
semanticscholar +1 more source
Both electrical and metabolic coupling shape the collective multimodal activity and functional connectivity patterns in beta cell collectives: A computational model perspective [PDF]
arXiv, 2023 Pancreatic beta cells are coupled excitable oscillators that synchronize their activity via different communication pathways. Their oscillatory activity manifests itself on multiple timescales and consists of bursting electrical activity, subsequent oscillations in the intracellular Ca2+, as well as oscillations in metabolism and exocytosis.
arxiv
Sustained exocytosis after action potential-like stimulation at low frequencies in mouse chromaffin cells depends on a dynamin-dependent fast endocytotic process [PDF]
, 2016 Under basal conditions the action potential firing rate of adrenal chromaffin cells is lower than 0.5 Hz. The maintenance of the secretory response at such frequencies requires a continuous replenishment of releasable vesicles.
Alvarez, Yanina Daniela +7 more
core +1 more source
HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells
Frontiers in Cellular Neuroscience, 2019 Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the quality of life.
Gaurav Datta +4 more
doaj +1 more source
Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex
PLoS Biology, 2014 Astrocytes secrete ATP by exocytosis from synaptic-like vesicles, activating neuronal P2X receptors, which contribute to postsynaptic GABA receptor down-regulation, ultimately mediating the communication between astrocytes and neurons required for brain ...
U. Lalo +5 more
semanticscholar +1 more source