Results 111 to 120 of about 21,092 (247)

Thermodynamic Efficiency of Somatic Exocytosis of Serotonin

Frontiers in Physiology, 2019
Through somatic exocytosis neurons liberate immense amounts of transmitter molecules that modulate the functioning of the nervous system. A stream of action potentials triggers an ATP-dependent transport of transmitter-containing vesicles to the plasma ...
Paula Noguez, J. Miguel Rubí, Francisco F. De-Miguel   +2 more
doaj   +1 more source

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

Sensing Exocytosis and Triggering Endocytosis at Synapses: Synaptic Vesicle Exocytosis–Endocytosis Coupling

Frontiers in Cellular Neuroscience, 2018
The intact synaptic structure is critical for information processing in neural circuits. During synaptic transmission, rapid vesicle exocytosis increases the size of never terminals and endocytosis counteracts the increase. Accumulating evidence suggests
Xuelin Lou
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Progress in the Role of Mast Cells and Biomolecular Signals in the Mechanism of Postoperative Ileus: From Cellular Activation to Exploration of the Brain–Gut Axis

Gut Medicine, EarlyView.
ABSTRACT Postoperative ileus (POI) is a frequent complication after surgical procedures, predominantly manifesting as aberrant gastrointestinal motility, which markedly extends the duration of postoperative recovery for patients. The clinical duration of POI is typically modulated by intricate inflammatory cascades, with mast cells assuming a critical ...
Tian‐le Zhang, Miao‐ying Geng, Ming‐yue Shao, Gang Wang, Zhi‐wei Jiang   +4 more
wiley   +1 more source

Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health

Ibrain, EarlyView.
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi, Aarzoo, Chakkaravarthi Saravanan, Heera Ram, Bhim Pratap Singh   +4 more
wiley   +1 more source

Regulated exocytosis per partes

, 2012
This Special Issue (SI) of Cell Calcium focuses on regulated exocytosis, a recent evolutionary invention of eukaryotic cells. This essential cellular process consists of several stages: (i) the delivery of membrane bound vesicles to specific plasma ...
Zorec, Robert, Coorssen, Jens R. (R12196)   +1 more
core   +1 more source

Long‐term clinical trajectory of microvillus inclusion disease associated with STXBP2‐related familial hemophagocytic lymphohistiocytosis type 5: A case report

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Familial hemophagocytic lymphohistiocytosis type 5 is caused by biallelic pathogenic variants in STXBP2, which encodes syntaxin‐binding protein, a key regulator of vesicle trafficking. In addition to immune dysregulation, patients with familial hemophagocytic lymphohistiocytosis type 5 may present with severe, persistent diarrhea associated ...
Hiroyuki Tanaka, Mariko Sekiguchi, Yuko Kajiho, Tetsuo Ushiku, Jun Fujishiro, Motohiro Kato   +5 more
wiley   +1 more source

Exocytosed ATP as a therapeutic target for inflammatory and metabolic diseases

Frontiers in Pharmacology
Extracellular adenosine triphosphate (eATP) is a key intercellular signaling molecule in purinergic transmission and contributes to pain, inflammation, and tissue dysfunction in a wide range of diseases. Although eATP is released through membrane damage,
Nao Hasuzawa, Seiji Nomura, Sawako Moriyama, Yoshinori Moriyama, Masatoshi Nomura   +4 more
doaj   +1 more source