Results 91 to 100 of about 99,750 (290)

Measuring calcium signals and exocytosis in tissues

, 2012
Background: Since the 1960s it has been clear that calcium is a key regulator of exocytosis. Early experiments directly showed that the secretory output was calcium dependent.
Thorn, Peter
core   +1 more source

Multivesicular exocytosis in rat pancreatic beta cells [PDF]

, 2011
AIMS/HYPOTHESIS: To establish the occurrence, modulation and functional significance of compound exocytosis in insulin-secreting beta cells. METHODS: Exocytosis was monitored in rat beta cells by electrophysiological, biochemical and optical methods. The
Ramracheya, R., Eliasson, Lena, Monteith, A. G., Galvanovskis, J, Zhang, Q., Monteith, A G, Macdonald, P E, P. E. MacDonald, Jones, E., Galvanovskis, J., Barg, S., C. Genoud, Clark, A., M. B. Hoppa, Hoppa, M. B., S. Barg, Karanauskaite, J, Collins, S C, J. Galvanovskis, E. Jones, Hoppa, M B, Q. Zhang, Jones, E, MacDonald, P. E., Eliasson, L, Genoud, C, Rorsman, P, Braun, M., A. G. Monteith, A. Clark, Barg, Sebastian,, M. Braun, R. Ramracheya, J. Karanauskaite, Genoud, C., Zhang, Q, S. C. Collins, Rorsman, P., L. Eliasson, P. Rorsman, Clark, A, Collins, S. C., Braun, M, Ramracheya, R, Karanauskaite, J., Lund University., Eliasson, L., Eliasson, Lena,   +47 more
core   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

A Novel Anti-Inflammatory Effect for High Density Lipoprotein.

PLoS ONE, 2015
High density lipoprotein has anti-inflammatory effects in addition to mediating reverse cholesterol transport. While many of the chronic anti-inflammatory effects of high density lipoprotein (HDL) are attributed to changes in cell adhesion molecules ...
Scott J Cameron, Craig N Morrell, Clare Bao, AnneMarie F Swaim, Annabelle Rodriguez, Charles J Lowenstein   +5 more
doaj   +1 more source

Regulated exocytosis per partes

, 2012
This Special Issue (SI) of Cell Calcium focuses on regulated exocytosis, a recent evolutionary invention of eukaryotic cells. This essential cellular process consists of several stages: (i) the delivery of membrane bound vesicles to specific plasma ...
Zorec, Robert, Coorssen, Jens R. (R12196)   +1 more
core   +1 more source

RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies

Advanced Science, EarlyView.
Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao, Taijiang Hou, Lin Zhang, Feng Gao, Tong Xing   +4 more
wiley   +1 more source

Nonlytic Exocytosis of Cryptococcus neoformans from Macrophages Occurs In Vivo and Is Influenced by Phagosomal pH

mBio, 2011
A unique aspect of the interaction of the fungus Cryptococcus neoformans with macrophages is the phenomenon of nonlytic exocytosis, also referred to as “vomocytosis” or phagosome extrusion/expulsion, which involves the escape of fungal cells from the ...
André Moraes Nicola, Emma J. Robertson, Patrícia Albuquerque, Lorena da Silveira Derengowski, Arturo Casadevall   +4 more
doaj   +1 more source

Animal models for investigating post‐stroke cognitive impairment: A neurovascular trafficking perspective

Animal Models and Experimental Medicine, EarlyView.
Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley   +1 more source