Results 81 to 90 of about 21,092 (247)

A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells.

PLoS ONE, 2012
Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca(2+)-dependent zymogen granule (ZG) exocytosis in ...
Sho Ogata, Takashi Miki, Susumu Seino, Seiichi Tamai, Haruo Kasai, Tomomi Nemoto   +5 more
doaj   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Exocytosis and Endocytosis: Yin-Yang Crosstalk for Sculpting a Dynamic Growing Pollen Tube Tip

Frontiers in Plant Science, 2020
The growing pollen tube has become one of the most fascinating model cell systems for investigations into cell polarity and polar cell growth in plants.
Lifeng Zhao, Muhammad Saad Rehmani, Hao Wang   +2 more
doaj   +1 more source

Imaging large cohorts of single ion channels and their activity [PDF]

, 2013
As calcium is the most important signaling molecule in neurons and secretory cells, amongst many other cell types, it follows that an understanding of calcium channels and their regulation of exocytosis is of vital importance.
Euan R. Brown, Katia eHiersemenzel, Brown, Euan R; id_orcid, Katia Hiersemenzel, Rory R. Duncan, Duncan, Rory R, Hiersemenzel, Katia, Rory R Duncan, Euan R Brown   +8 more
core   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

A primordial synaptotagmin-independent function of complexin in regulated exocytosis

Nature Communications
In Ca²⁺-triggered exocytosis such as synaptic neurotransmitter release, vesicle fusion is tightly regulated by synaptotagmin (Syt) and complexin (Cpx), which together clamp partially assembled SNARE complexes to prevent premature fusion.
Xu Chen, Chun Wan, Jingyi Wu, Yan Ouyang, Harrison Puscher, Haijia Yu, Jingshi Shen   +6 more
doaj   +1 more source

HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

Frontiers in Cellular Neuroscience, 2019
Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the quality of life.
Gaurav Datta, Nicole M. Miller, Zahra Afghah, Jonathan D. Geiger, Xuesong Chen   +4 more
doaj   +1 more source

Mechanisms and Function of Dendritic Exocytosis [PDF]

, 2011
Dendritic exocytosis is required for a broad array of neuronal functions including retrograde signaling, neurotransmitter release, synaptic plasticity, and establishment of neuronal morphology.
Matthew J. Kennedy, Kennedy, Matthew J., Michael D. Ehlers, Ehlers, Michael D.   +3 more
core   +1 more source

A Novel Anti-Inflammatory Effect for High Density Lipoprotein.

PLoS ONE, 2015
High density lipoprotein has anti-inflammatory effects in addition to mediating reverse cholesterol transport. While many of the chronic anti-inflammatory effects of high density lipoprotein (HDL) are attributed to changes in cell adhesion molecules ...
Scott J Cameron, Craig N Morrell, Clare Bao, AnneMarie F Swaim, Annabelle Rodriguez, Charles J Lowenstein   +5 more
doaj   +1 more source

Statistical analysis of exocytosis in the INS-1 cell line using different depolarization protocols to increase knowledge of human beta cells

, 2023
reservedLe cellule β pancreatiche, che si trovano nelle isole di Langerhans all'interno del pancreas, sono responsabili della sintesi e della secrezione insulinica.
VOLGGER, MARTINA
core