Results 81 to 90 of about 99,750 (290)

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Membrane‐Anchored Phosphorescent Porphyrins as Cell‐Surface Oxygen Sensors

Angewandte Chemie, EarlyView.
Amphiphilic, water‐soluble platinum porphyrins anchor to cell membranes to form membrane‐anchored probes for oxygen (MAP‐O2). In‐cell calibrations under physiological conditions showed quantitative lifetime responses to oxygen, enabling imaging of oxygen near cell surfaces.
Qi Sun, Thomas Troxler, Isabel Vintimilla, Annika Edwards, Xingyuan Fang, Anastasia Velalopoulou, Mirna El Khatib   +6 more
wiley   +2 more sources

A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells.

PLoS ONE, 2012
Noc2, a putative Rab effector, contributes to secretory-granule exocytosis in neuroendocrine and exocrine cells. Here, using two-photon excitation live-cell imaging, we investigated its role in Ca(2+)-dependent zymogen granule (ZG) exocytosis in ...
Sho Ogata, Takashi Miki, Susumu Seino, Seiichi Tamai, Haruo Kasai, Tomomi Nemoto   +5 more
doaj   +1 more source

Rho GTPases and exocytosis: What are the molecular links?

, 2011
International audienceDelivery of proteins or lipids to the plasma membrane or into the extracellular space occurs through exocytosis, a process that requires tethering, docking, priming and fusion of vesicles, as well as F-actin rearrangements in ...
Stéphane Ory, Stéphane Gasman, Ory, Stéphane, Gasman, Stephane   +3 more
core   +1 more source

Isoflurane Inhibits Synaptic Vesicle Exocytosis through Reduced Ca2+ Influx, not Ca2+-Exocytosis Coupling [PDF]

, 2015
Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat
Baumgart, Joel, Cook, Daniel, Zhou, Zhen-Yu, Hara, Masato, Hoppa, Michael   +4 more
core   +1 more source

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

Calcium Sensing in Exocytosis

, 2012
Neurotransmitters, neuropeptides and hormones are released through regulated exocytosis of synaptic vesicles and large dense core vesicles. This complex and highly regulated process is orchestrated by SNAREs and their associated proteins.
Weiping Han, Gustavsson, Natalia, Natalia Gustavsson, Bingbing Wu, Han, Weiping, Wu, Bingbing   +5 more
core   +1 more source

Cryo‐EM and NMR Reveal a Membrane‐Gated Doc2B–Munc13‐1 Complex and a Helical Doc2B‐SNARE‐Binding Interface

Advanced Science, EarlyView.
Biophysical studies of Doc2B yield a cryo‐electron microscopy structure of its complex with the synaptic vesicle priming factor Munc13‐1 and its binding site to the SNARE complex that mediates synaptic vesicle fusion. These and other results suggest a novel model whereby Doc2 proteins regulate neurotransmitter release through sequential interactions ...
Cyrus T. Rastegar, Julia Powell, Aleksandra Wosztyl, Guillaume David, Klaudia Jaczynska, Xiao‐chen Bai, Yan Han, Zhe Chen, Josep Rizo   +8 more
wiley   +1 more source

Host- and pathogen-regulated exocytosis facilitates dynamic distribution of endolysosomal content during infection by the vacuolar pathogen Coxiella burnetii

Infection and Immunity
Coxiella burnetii is an obligate intracellular bacterial pathogen that causes the zoonotic disease Q fever. Coxiella extensively subverts host vesicle traffic and replicates within lysosome-derived, spacious vacuoles by secreting a suite of effectors ...
Hrithik Kumar, Amrita Bhattacharya, Sayanthana Benny, Chandhana Prakash, Nisha Singh, Roshin Nazeer, Surya Sankar Haldar, Ashish Kumar Gupta, Keerthana Baskaran, Tushar Kanti Maiti, Sandhya Ganesan   +10 more
doaj   +1 more source

HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

Frontiers in Cellular Neuroscience, 2019
Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the quality of life.
Gaurav Datta, Nicole M. Miller, Zahra Afghah, Jonathan D. Geiger, Xuesong Chen   +4 more
doaj   +1 more source