Results 251 to 260 of about 153,788 (344)

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis. [PDF]

Circ Res
Singhal A, Russo S, Dhawan UK, Bhutia K, Bell CG, Hayat H, Nightingale TD, de Gaetano M, Belton O, Brennan E, Munroe PB, Godson C, Barry M, Shoulders CC, Wilson HL, Velasco G, Kiss-Toth E, Subramanian M.   +17 more
europepmc   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

BACE1 Expression Is Required for Proper Synaptic Vesicle Dynamics in the Hippocampus. [PDF]

J Neurochem
Zhou J, Antic SD, Das B, He W, Tran DM, Hu X, Fernández-Chacón R, Yan R.   +7 more
europepmc   +1 more source

Proteomic analysis of sperm from fertile stallions and subfertile stallions due to impaired acrosomal exocytosis [PDF]

Camilo Hernández‐Avilés, Luisa Ramírez‐Agámez, Susan T. Weintraub, Charles F. Scoggin, Brian W. Davis, Terje Raudsepp, Dickson D. Varner, Charles C. Love   +7 more
openalex   +1 more source

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source

Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness

, 2018
Shu-Huei Cho, I‐Ying Kuo, Pei‐Jung Lu, Hong‐Tai Tzeng, Wu‐Wei Lai, Wu‐Chou Su, Yi‐Ching Wang   +6 more
openalex   +1 more source

The Calcium‐Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando, Guillermo Rodríguez‐Bey, Rosendo G. Hernández, Ángela Gento‐Caro, Ángel M. Pastor, Antonio Campos‐Caro, David González‐Forero, Bernardo Moreno‐López   +7 more
wiley   +1 more source

Microvesicles, exosomes and their combinations with cytoplasmic organelles: from their discovery to their innovative roles in clinical medicine. [PDF]

Biol Direct
Meldolesi J.
europepmc   +1 more source

Septin5 deletion enhances β-cell exocytosis by releasing microtubule-tethered insulin granules onto plasma membrane [PDF]

Li Xie, Fei Kang, Tairan Qin, Youhou Kang, Tao Liang, Huanli Xie, Carol D. Froese, Hong Xie, Aaron Au, Christopher M. Yip, William S. Trimble, Herbert Y. Gaisano   +11 more
openalex   +1 more source