Results 11 to 20 of about 416,673 (167)

Effect of exogenous phosphocreatine on endothelium and endothelium-dependent vascular reactions in immune cardiac injury

Current Therapeutic Research, 1992
Abstract A model of immune (cytotoxic) injury of the heart in the dog was used to evaluate the effects of exogenous phosphocreatine on the structure and function of coronary vessels. Immune damage was caused by administration of cytotoxic anticardiac serum (produced by immunization of rabbits by a supernatant obtained after centrifugation of dog ...
A.A. Moibenko, G.I. Marchenko, V.N. Kotsuruba, L.F. Popovich, V.K. Zrazhevskaya, V.A. Saks   +5 more
semanticscholar   +4 more sources

Exogenous Phosphocreatine Application in Elderly and Senile Patients Operated for Colorectal Cancer

Общая реаниматология, 2017
Objective: to evaluate the efficacy of exogenous phosphocreatine (EPCr) application in elderly and senile patients operated for colorectal cancer.Material and methods.
V. N. Derbugov, A. L. Potapov, V. I. Potievskaya, Ya. M. Khmelevski   +3 more
doaj   +2 more sources

Fusogenic Liposomes for the Intracellular Delivery of Phosphocreatine [PDF]

Pharmaceuticals
Background/Objective: Maintaining intracellular adenosine triphosphate (ATP) levels is essential for numerous cellular functions, including energy metabolism, muscle contraction, and nerve impulse transmission.
Okhil K. Nag, Eunkeu Oh, James B. Delehanty   +2 more
doaj   +2 more sources

Arginine: at the crossroads of nitrogen metabolism [PDF]

The EMBO Journal
L-arginine is the most nitrogen-rich amino acid, acting as a key precursor for the synthesis of nitrogen-containing metabolites and an essential intermediate in the clearance of excess nitrogen. Arginine’s side chain possesses a guanidino group which has
Tak Shun Fung, Keun Woo Ryu, Craig B Thompson   +2 more
doaj   +2 more sources

An Ion-Pair HPLC Method for Simultaneous Determination of Exogenous Phosphocreatine and Its Metabolite Creatine and Related ATP in Rabbit Plasma and RBC: Application to a Pharmacokinetic Study

Journal of Analytical Sciences, Methods and Instrumentation, 2013
A specific, precise and accurate ion-pair HPLC-UV method has been developed and validated for simultaneous determination of phosphocreatine (PCr), and its metabolite creatine (Cr) as well as related ATP in plasma and red blood cell (RBC) of rabbits. After addition of TMP as IS, the samples were deproteinized with 6% PCA. The analytes were separated
Li Lv, Heng Xi, Guozhu Han
openaire   +3 more sources

The use of exogenous phosphocreatine in surgical correction of valvular heart defects under cardiopulmonary bypass: a randomized, double-blind, placebo-controlled pilot study

Patologiya krovoobrashcheniya i kardiokhirurgiya
Introduction: Myocardial ischemia and stunning during cardiac surgery remain a common and serious complication of the perioperative period with a significant negative impact on patient outcomes, especially in high-risk patients. Experimental and clinical studies have demonstrated that the administration of exogenous phosphocreatine can reduce mortality
V.A. Boboshko, P.P. Perovskiy, V.N. Lomivorotov, A.N. Shilova, A.S. Zalesov, V.A. Nepomnyashchikh, V.Ya. Martynenkov, A.M. Chernyavskiy   +7 more
openaire   +2 more sources

Protection of ischemic myocardium by exogenous phosphocreatine

The Journal of Thoracic and Cardiovascular Surgery, 1987
V.G. Sharov, V.A. Saks, V.V. Kupriyanov, V.L. Lakomkin, V.I. Kapelko, A. Ya Steinschneider, S.A. Javadov   +6 more
exaly   +6 more sources

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart [PDF]

, 2014
Background: Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism.
Aksentijević, Dunja, Faller, Kiterie M.E., Lygate, Craig A., McAndrew, Debra J., Neubauer, Stefan, Schneider, Jurgen E., Zazueta, Cecilia, Zervou, Sevasti   +7 more
core   +12 more sources

α-Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons. [PDF]

J Physiol
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Tomagra G, Battaglia A, Franchino C, Bonzano S, Picollo F, Chiantia G, de Iure A, Calabresi P, Picconi B, Carbone E, De Marchis S, Marcantoni A, Carabelli V.   +12 more
europepmc   +2 more sources

The effect of exogenous phosphocreatine on the course of experimental contusion injury of the cornea

Oftalmologicheskii Zhurnal, 2013
E. Barinov, K. Golubov, O. Sulaeva
openaire   +2 more sources