Results 91 to 100 of about 40,676 (197)

Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane [PDF]

, 2019
Alternative Splicing (AS) is a mechanism that generates different mature transcripts from precursor mRNAs (pre-mRNAs) of the same gene. In plants, a wide range of physiological and metabolic events are related to AS, as well as fast responses to changes ...
Alabadí, Amorim, Annunziata, Annunziata, Beyer, Bieniawska, Calixto, Calixto, Calixto, Calixto, Chamala, Chan, Chaudhary, Cuadrado, Dantas, de Setta, Ding, Dodd, Dodd, D’Hont, D’Hont, Endo, Filichkin, Filichkin, Filichkin, Filichkin, Fouquet, Frank, Fung-Uceda, Garcia, Garsmeur, Godoy Herz, Graf, Graf, Graveley, Grundy, Göhring, Harmer, Haydon, Higashi, Hotta, Hsu, Iskandar, Izawa, Izawa, Jabre, Jacob, James, James, James, Jones, Kalyna, Khan, Ko, Kornblihtt, Kriechbaumer, Kwon, Lai, Liu, Locke, Lu, Marquez, Marshall, Mastrangelo, McClung, McCormick, Millar, Miller, Min, Moll, Moore, Murakami, Nagano, Nagashima, Nakamichi, Ng, Ni, Oesterreich, Palusa, Para, Park, Pokhilko, Reddy, Remy, Riaño-Pachón, Richards, Rosloski, Saldi, Sato, Seo, Seo, Severing, Shalit-Kaneh, Shang, Shen, Simpson, Simpson, Souza, Staiger, Staiger, Sugliani, Syed, Szakonyi, Thatcher, Vaneechoutte, Vicentini, Wang, Zeilinger, Zhang, Zhang, Zhang, Zhang   +111 more
core   +2 more sources

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice

Molecular Therapy: Nucleic Acids, 2017
Spinocerebellar ataxia type 3 (SCA3) is a currently incurable neurodegenerative disorder caused by a CAG triplet expansion in exon 10 of the ATXN3 gene.
Lodewijk J.A. Toonen, Frank Rigo, Haico van Attikum, Willeke M.C. van Roon-Mom   +3 more
doaj   +1 more source

Identification of novel transcripts and peptides in developing murine lens. [PDF]

, 2018
We previously investigated the transcriptome and proteome profiles of the murine ocular lens at six developmental time points including two embryonic (E15 and E18) and four postnatal time points (P0, P3, P6, and P9).
Ali, Muhammad, Chen, Ruiqiang, Hackett, Sean F, Kabir, Firoz, Khan, Shahid Y, Lee, Mei-Chong W, Na, Chan Hyun, Pourmand, Nader, Riazuddin, S Amer   +8 more
core   +1 more source

Repurposing Dantrolene for Long-Term Combination Therapy to Potentiate Antisense-Mediated DMD Exon Skipping in the mdx Mouse

Molecular Therapy: Nucleic Acids, 2018
Duchenne muscular dystrophy (DMD) is caused by mutations in DMD, resulting in loss of dystrophin, which is essential to muscle health. DMD “exon skipping” uses anti-sense oligo-nucleotides (AONs) to force specific exon exclusion during mRNA processing to
Derek W. Wang, Ekaterina I. Mokhonova, Genevieve C. Kendall, Diana Becerra, Yalda B. Naeini, Rita M. Cantor, Melissa J. Spencer, Stanley F. Nelson, M. Carrie Miceli   +8 more
doaj   +1 more source

Trans‐generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy

EMBO Molecular Medicine, 2020
Exon skipping is an effective strategy for the treatment of many Duchenne Muscular Dystrophy (DMD) mutations. Natural exon skipping observed in several DMD cases can help in identifying novel therapeutic tools.
Julie Martone, Michela Lisi, Francesco Castagnetti, Alessandro Rosa, Valerio Di Carlo, Enrique Blanco, Adriano Setti, Davide Mariani, Alessio Colantoni, Tiziana Santini, Lucia Perone, Luciano Di Croce, Irene Bozzoni   +12 more
doaj   +1 more source

rMAPS: RNA map analysis and plotting server for alternative exon regulation. [PDF]

, 2016
RNA-binding proteins (RBPs) play a critical role in the regulation of alternative splicing (AS), a prevalent mechanism for generating transcriptomic and proteomic diversity in eukaryotic cells.
Jung, Sungbo, Park, Juw Won, Rouchka, Eric C, Tseng, Yu-Ting, Xing, Yi   +4 more
core   +2 more sources

Exon Skipping Approach to Duchenne Muscular Dystorphy

Rinsho Shinkeigaku, 2014
Exon skipping therapy by antisense oligonucleotide is a promising approach to Duchenne muscular dystrophy (DMD). We have reported the proof-of-concept studies using morpholino on mice or dog DMD model and on patient derived cells. Based on these results, we had promoted collaborative research with a Japanese pharmaceutical company and encouraged ...
openaire   +3 more sources

MDM4 exon skipping upon dysfunctional ribosome assembly

Trends in Cell Biology
Recent studies revealed how nucleolar stress enhances MDM4 exon skipping and activates p53 via the ribosomal protein L22 (RPL22; eL22). Tumor-associated L22 mutations lead to full-length MDM4 synthesis, overcoming tumor suppression by p53. This forum article explores how MDM4 splicing patterns integrate stress signaling to take p53-dependent cell fate ...
Jennifer Jansen, Matthias Dobbelstein
openaire   +4 more sources

Exon Skipping of Cathepsin B [PDF]

Journal of Biological Chemistry, 2004
Kathrin Müntener, Roman Zwicky, Gabor Csucs, Jack Rohrer, Antonio Baici   +4 more
openaire   +1 more source

Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates. [PDF]

, 2008
Cyclic AMP-dependent protein kinase (PKA) is a holoenzyme composed of two catalytic (C) subunits and a regulatory (R) subunit dimer. The holoenzyme dissociates when four cAMP molecules bind to the R subunit dimer.
Avellan, Cecilia I. A.
core