Results 101 to 110 of about 838,049 (387)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Urease: Kinetic and Thermodynamic Mechanisms and Their Diverse Applications

Exon
Microbial urease (amidohydrolase, EC 3.5.1.5) is a metalloenzyme of significant biological and ecological importance, widely distributed among various microorganisms including bacteria, fungi, and archaea.
Amiya Ojha, Tapa Manna, Anjilesh Kumar, Partho Shit, Megha Mete, Deeplina Das, Tarun Kanti Bandyopadhyay   +6 more
doaj   +1 more source

Accurate clinical detection of exon copy number variants in a targeted NGS panel using DECoN

Wellcome Open Research, 2016
Background: Targeted next generation sequencing (NGS) panels are increasingly being used in clinical genomics to increase capacity, throughput and affordability of gene testing.
Anna Fowler, S. Mahamdallie, Elise Ruark, S. Seal, Emma Ramsay, M. Clarke, I. Uddin, Harriett Wylie, Ann Strydom, G. Lunter, N. Rahman   +10 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Seroprevalence of Hepatitis B Virus Among individuals aged 15 and above in Bova, Southwest Cameroon: A Community-Based Survey

Exon
Background: Hepatitis B virus infection is one of the most common sexually transmitted diseases. It causes severe damage to the liver there by obstructing its functioning. However, some communities are not aware of its severity. Objective: To assess
Jemea Lyonga Ngoisah, Elisabeth Zeuko’o Menkem, Eleonore Ngounou, Elizabeth Ayuk Ndip, Fanuella Binwie Shu, Evaris Paddy Nchianang Fonyuy, Rex Mbah Tendong, Constantine Ndikum Njikem, Arnaud Fondjo Kouam, Fabrice Fekam Boyom   +9 more
doaj   +1 more source

The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients [PDF]

, 2008
We investigated the relationships between functional genetic variants of the 5-HT(2C) receptor and multidrug-resistant protein (MDR1), coding for P-glycoprotein, and second generation antipsychotic (SDA)-induced weight gain among 108 female schizophrenic
Bilušić, Hrvoje, Božina, Nada, Hotujac, Ljubomir, Medved, Vesna, Rojnić Kuzman, Martina, Šain, Ivica   +5 more
core   +1 more source

In Vivo Recognition of a Vertebrate Mini-Exon as an Exon-Intron-Exon Unit

Molecular and Cellular Biology, 1993
Very small vertebrate exons are problematic for RNA splicing because of the proximity of their 3' and 5' splice sites. In this study, we investigated the recognition of a constitutive 7-nucleotide mini-exon from the troponin I gene that resides quite close to the adjacent upstream exon.
D A, Sterner, S M, Berget
openaire   +3 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Unveiling Urease Inhibitory Properties and Phytochemical Screening for the Therapeutic Potential of Extracts and Fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr

Exon
Urease is an enzyme that plays a significant role in the pathogenesis of Helicobacter pylori responsible for numerous health issues, among which chronic gastritis, peptic ulcer disease, gastric neoplasia and even stomach cancer.
Doriane Perlise Lienou, Corinne Raïssa Ngnameko, Fils Armand Ella, Marie Atsama Amougou, Arnaud Fondjo Kouam, Jacqueline Njikam Manjia, Fredy Brice Nemg Simo, Frederic Nico Njayou, Paul Fewou Moundipa   +8 more
doaj   +1 more source

Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms [PDF]

, 2006
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by
Brower, Christopher S., Davydov, Ilia V., Hu, Rong-Gui, Kwon, Yong Tae, Sheng, Jun, Varshavsky, Alexander, Wang, Haiqing, Zhou, Jianmin   +7 more
core   +2 more sources