Results 211 to 220 of about 838,175 (338)

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Alternative splicing in voltage-gated sodium channels: mechanisms, regulatory networks and therapeutic implications. [PDF]

Ann Med
Qiu J, Wu P, Zhang Y, Li Y, Xia C, Peng S, Sun J.   +6 more
europepmc   +1 more source

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping.

Cancer Discovery, 2015
P. Paik, A. Drilon, P. Fan, H. Yu, N. Rekhtman, M. Ginsberg, L. Borsu, N. Schultz, M. Berger, C. Rudin, M. Ladanyi   +10 more
semanticscholar   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

PCBP1 regulates alternative splicing of AARS2 in congenital cardiomyopathy. [PDF]

Nat Cardiovasc Res
Lu YW, Liang Z, Dorr K, Ruiz S, Huang X, Fangnibo Hanvi D, Juntilla SM, Beutner G, Lyu S, Guo H, Fernandes T, Espinoza-Lewis RA, Wang T, Li K, Li X, Bir Singh G, Wang Y, Deng R, Cowan D, Mably JD, Pu WT, Huang J, Porter GA, Conlon F, Chen H, Wang DZ.   +25 more
europepmc   +1 more source

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Cancer Cell, 2015
Eunhee Kim, J. Ilagan, Yang Liang, G. M. Daubner, Stanley C. Lee, Aravind Ramakrishnan, Aravind Ramakrishnan, Yue Li, Y. R. Chung, J. Micol, Michele E. Murphy, Hana Cho, Min Kyung Kim, Ahmad S. Zebari, Shlomzion Aumann, Christopher Y. Park, S. Buonamici, Peter G. Smith, H. J. Deeg, H. J. Deeg, Camille Lobry, Camille Lobry, I. Aifantis, Y. Modis, Y. Modis, F. Allain, Stephanie Halene, R. Bradley, O. Abdel-Wahab   +28 more
semanticscholar   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Pathogenic Analysis of Two <i>SLC22A5</i> Variants That Alter RNA Splicing in Patients with Primary Carnitine Deficiency. [PDF]

Int J Neonatal Screen
Lin Y, Chen Y, Lin W, Zheng F.
europepmc   +1 more source

Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping

Journal of Thoracic Oncology, 2016
R. Heist, L. Sequist, D. Borger, J. Gainor, R. Arellano, L. Le, D. Dias-Santagata, Jeffrey W. Clark, J. Engelman, A. Shaw, J. Iafrate   +10 more
semanticscholar   +1 more source