Results 341 to 350 of about 838,049 (387)

EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment

Nature Reviews Clinical Oncology, 2021
Alex Friedlaender, Vivek Subbiah, Alessandro Russo   +2 more
exaly   +2 more sources

Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue

Nature Biotechnology, 2022
Single-nuclei RNA sequencing characterizes cell types at the gene level. However, compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack barcodes and hinder the study of isoforms.
Wen Hu, Anoushka Joglekar, Li Fan
exaly   +2 more sources

Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions.

New England Journal of Medicine, 2023
BACKGROUND Amivantamab has been approved for the treatment of patients with advanced non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertions who have had disease progression during or after platinum-based ...
Caicun Zhou, Ke-jing Tang, B. Cho, Baogang Liu, L. Paz-Ares, Susanna Y. Cheng, Satoru Kitazono, M. Thiagarajan, J. Goldman, J. Sabari, R. Sanborn, Aaron S. Mansfield, Jen-Yu Hung, Michael Boyer, Sanjay Popat, J. Mourão Dias, E. Felip, M. Majem, Mahmut Gumus, Sang-we Kim, A. Ono, John Xie, A. Bhattacharya, Trishala Agrawal, S. M. Shreeve, R. Knoblauch, Keunchil Park, Nicolas Girard   +27 more
semanticscholar   +1 more source

Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

Nature Medicine, 2018
Jacqulyne Robichaux, Yasir Y Elamin, Zhi Tan   +2 more
exaly   +2 more sources

Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

Signal Transduction and Targeted Therapy, 2019
Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor (EGFR) gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer (NSCLC).
Simon Vyse, Paul H Huang
exaly   +2 more sources

The exon junction complex as a node of post-transcriptional networks

Nature Reviews Molecular Cell Biology, 2015
Hervé Le Hir
exaly   +2 more sources

Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer

Science Translational Medicine, 2013
Hiroyuki Yasuda, Antonio R Lucena-Araujo, Geoffrey R Oxnard   +2 more
exaly   +2 more sources

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

Cell Research, 2013
Although the function of DNA methylation in gene promoter regions is well established in transcriptional repression, the function of the evolutionarily conserved widespread distribution of DNA methylation in gene body regions remains incompletely ...
Alika K Maunakea, Iouri Chepelev, Kairong Cui   +2 more
exaly   +2 more sources

Alternative splicing and evolution: diversification, exon definition and function

Nature Reviews Genetics, 2010
Hadas Keren, Galit Lev-Maor, G. Ast
exaly   +2 more sources