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Isolation of Exons from Cloned DNA by Exon Trapping
Current Protocols in Human Genetics, 1994AbstractExon trapping is an RNA polymerase chain reaction (PCR) method to clone expressed sequences or exons directly from mammalian genomic DNA. The basic protocol in this unit describes the method for trapping internal exons from cosmid clones and the second basic protocol describes trapping of 3 terminal exons.
P E, Nisson, P C, Watkins, D B, Krizman
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Exons – Introns = Lexons: In‐frame concatenation of exons by PCR
Human Mutation, 1998A method for concatenating exons from genomic DNA, thereby skipping large stretches of intron sequence, has been developed using the polymerase chain reaction (PCR) with primers based on known intron-exon junction sequences. The use of genomic DNA circumvents the need for cDNA preparation for many purposes, including cDNA construction and mutational ...
T M, Tuohy, J, Groden
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Nature Reviews Genetics, 2019
A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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Exon–exon junction – what's your function?
Trends in Cell Biology, 2001The expression of aberrant proteins can have disastrous consequences for a cell. Quality-control mechanisms that survey newly synthesized mRNAs are therefore essential to cellular well being. Unspliced pre-mRNAs are retained in the nucleus because they fail to associate with the appropriate export factors.
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Exon-intron circular RNAs regulate transcription in the nucleus
Nature Structural &Molecular Biology, 2015Zhaoyong Li +17 more
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TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
Nature, 2022X Rosa, Mercedes Prudencio, Yuka Koike
exaly