Results 81 to 90 of about 394,574 (252)

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Assessment of Proximate, Mineral and amino acid Profile of Selected Agro-Allied By-Products Residues in Umuagwo, Imo State Nigeria

Exon
This study presents the first comparative analysis of proximate, mineral and amino acid composition of selected agricultural crop residues as potential feed ingredients in livestock and poultry production.
JohnPaul Nnawuike Azorji, Ohanusi I, Arodiogbu Francis Uche, Uzowulu Ebere, Okafor Justina Ogbonna, Onyekachi Uju Tilda, Amadi J.E.C   +6 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Sustainable Conversion of Chitosan Waste into Nitrogen-Doped Graphene Quantum Dots: Green Synthesis Pathways and Biomedical Potential

Exon
The sustainable conversion of bio-waste into functional nanomaterials represents a critical step toward achieving circular material cycles and environmentally responsible innovation.
B Sooryakanth, M R Rajan, S Sudhabose, Sangeetha Arulalan, Brindha B, Ruthra R, Shakila Venkatesan, Aswathy V   +7 more
doaj   +1 more source

Patient‐Derived 3D Bioprinted Cardiac Organoid Constructs Reveal Key Pathological Features of Duchenne Muscular Dystrophy

Advanced Healthcare Materials, EarlyView.
Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini, Margalida Campaner Socias, Andreas Dimopoulos, Lorenza Rinvenuto, Enrico Pozzo, Diana Stalkopf, Angelo Serafini, Sara Morri, Ashley Wang, Rita La Rovere, Yoke Chin Chai, Sveva Bollini, Geert Bultynck, H. Llewelyn Roderick, Ioannis Papantoniou, Maurilio Sampaolesi   +15 more
wiley   +1 more source

Phytochemical profiling, antioxidant, antimicrobial and cytotoxic evaluation of Bergera koenigii seed extracts against Leukemic cancer

Exon
Traditional herbs have always been pioneers in the development of new therapeutics. According to Ayurveda, India has always been a hub of many herbs and shrubs that possess numerous polyphenols and flavonoids with promising anticancer, antioxidant, and ...
Balaji Govindaswamy, Trini Mary Infanta, Murugappan Kumarappan   +2 more
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Monogenic Diabetes: Genetic Insight and Precision Therapeutics in the Management of MODY

Exon
A monogenic diabetes, specifically, the Maturity-onset diabetes of the young (MODY) is the consequence of the single-gene mutations that are responsible for transcription factors such as HNF1A and GCK taking effect on the insulin synthesis, glucose ...
Gayathri Venkatesan, Kala vetha Kumari, Ariya S S, Princy Vijayababu   +3 more
doaj   +1 more source

Microfluidic Hydroporation Platform for Effective Allogeneic CAR‐T Cell Production and Subsequent Functional Cytotoxicity Analysis

Advanced Materials Technologies, EarlyView.
The hydroporator platform employs controlled hydrodynamic deformation for efficient mRNA and CRISPR/Cas9 delivery into primary human T cells, enabling allogeneic CAR‐T cell manufacturing. It preserves cell functionality and drives potent gene editing, CAR expression, and tumor cytotoxicity, while feature‐based analysis links these functional outcomes ...
Soohyun Jeon, Sein Kim, Hyun‐Young Kim, Duck Cho, Sungsu Park, Seohyun Kim, Aram J. Chung   +6 more
wiley   +1 more source

Chemical Memory in Primitive Organisms: Evolutionary Insights and Mechanistic Perspectives

Exon
Memory, the cornerstone of adaptive behavior, has been extensively studied within the confines of neural systems. A comprehensive literature review was conducted using key academic databases such as PubMed, Web of Science, and Google Scholar.
Saad Ahmed, Haris Ishtiaq Kiani, Muhammad Fahad Shabbir   +2 more
doaj   +1 more source