Results 181 to 190 of about 586,929 (366)

Universal alternative splicing of noncoding exons

bioRxiv, 2017
I. Deveson, M. Brunck, J. Blackburn, Elizabeth Tseng, T. Hon, Tyson A. Clark, M. Clark, J. Crawford, M. Dinger, L. Nielsen, J. Mattick, T. Mercer   +11 more
semanticscholar   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression

Advanced Science, EarlyView.
This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang, Dan‐Yang Yuan, Yu‐Jia Lu, Xin Wang, Hao Zheng, Lin Li, She Chen, Xin‐Jian He   +7 more
wiley   +1 more source

Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population

, 2008
David Millar, Mark Lewis, Martin Horan, Vicky Newsway, Aled Rees, Tammy E. Easter, Guglielmina Pepe, Olga Rickards, Martin Norin, M. F. Scanlon, Michael Krawczak, D.N. Cooper   +11 more
openalex   +2 more sources

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Updated nomenclature for human and mouse neurofibromatosis type 1 genes [PDF]

, 2017
Anastasaki, Corina, Gutmann, David H, Kesterson, Robert A, Le, Lu Q   +3 more
core   +2 more sources

A novel deletion involving GNAS exon 1 causes PHP1A and further refines the region required for normal methylation at exon A/B

, 2017
Monica Reyes, Anara Karaca, Murat Bastepe, Neşe Ersöz Gülçelik, Harald Jüppner   +4 more
openalex   +1 more source

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers [PDF]

, 2016
Leonard D. Goldstein, James Lee, Florian Gnad, Christiaan Klijn, Annalisa Schaub, Jens Reeder, Anneleen Daemen, Corey E. Bakalarski, Thomas Holcomb, David S. Shames, Ryan J. Hartmaier, Juliann Chmielecki, Somasekar Seshagiri, Robert Gentleman, David Stokoe   +14 more
openalex   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Association of DRD2 (rs 1799732), ANKK1 (rs1800497), DAT (rs28363170), DRD4 (exon 3 - VNTR) gene polymorphisms in the context of relapses in therapy. [PDF]

, 2020
Jolanta Chmielowiec, Agnieszka Boroń
openalex   +1 more source